Results 211 to 220 of about 106,824 (308)

Decreased Expression of FAT4 Promotes Multiple Myeloma Proliferation and Migration by Targeting the Hippo/YAP Pathway

Cancer Science, EarlyView.
This study provides the first comprehensive characterization of the functional impact, and mechanistic role of FAT4 in MM. Our findings highlight the tumor‐suppressive role of FAT4 in MM and uncover a novel mechanism by which FAT4 regulates the Hippo/YAP pathway.
Lina Zhang, Na Shen, Xin Cheng, Qinglin Shi, Lijuan Chen, Xuxing Shen   +5 more
wiley   +1 more source

Transcriptome profiling of intra-snail stages of the liver fluke Fasciola hepatica reveals key mediators underlying parasite development and interaction with the host. [PDF]

BMC Genomics
Langleib M, Fontenla S, Domínguez F, Sankaranarayanan G, Wlodek S, Berriman M, Rinaldi G, Iriarte A, Tort JF.   +8 more
europepmc   +1 more source

Epithelial YPEL3 Modulates CD8+ T‐Cell Infiltration and Tumor Progression Through CREB1–CXCL16 Signaling in HNSCC

Cancer Science, EarlyView.
YPEL3 functions as a tumor suppressor in HNSCC by inhibiting tumor progression and promoting apoptosis. Mechanistically, it enhances epithelial–immune crosstalk through the CREB1‐mediated CXCL16–CXCR6 axis, facilitating CD8+ T‐cell infiltration and highlighting its potential as a prognostic biomarker and immunotherapy target.
Yalun Li, Yumei Li, Caiyu Sun, Congxian Lu, Gang Chen, Tianshu Zhou, Bei Zhang, Xicheng Song   +7 more
wiley   +1 more source

<i>Schistosomiasis japonicum</i> in Indonesia: Progress and Surveillance Needs in Verge-of-Elimination Settings. [PDF]

Trop Med Infect Dis
Azhari AN, Putri AZ, Diptyanusa A, Sunardi S, Hapsari YA, Sidjabat RT, Ariyanti D, Khoirudin Z, Rezavitawanti R, Herdiana H, Yuzwar YE, Alhosani F.   +11 more
europepmc   +1 more source

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

Expanded molecular evidence of soil-transmitted helminth and Schistosoma spp. infections in Myanmar schoolchildren: A qPCR update. [PDF]

PLoS Negl Trop Dis
Aung E, Collinson N, Han KT, Hlaing NN, Aye MM, Htun MW, Wai KT, Myat SM, Thwe TL, Tun A, Wangdi K, Li Y, Williams GM, Clements ACA, Nery SV, McManus DP, Gray DJ, Gordon CA.   +17 more
europepmc   +1 more source

Strategic conservation prioritization through creating and updating the regional species of greatest conservation need list in the northeastern United States

Conservation Science and Practice, EarlyView.
Biodiversity is declining globally, underscoring the need for conservation strategies informed by regional expertise. In the northeastern United States, 14 state wildlife agencies and taxonomic experts developed the Regional Species of Greatest Conservation Need (RSGCN) list, revealing that global and national datasets captured only ~55% of regionally ...
Melissa D. Starking, Tracy Monegan Rice, Karen Terwilliger, Donovan Drummey, Mack Frantz, Catherine D. Haffner, Brian Hess, Lisa Holst, Michael Marchand, Kevin R. Burgio   +9 more
wiley   +1 more source

Limited impact of schistosome infection on Biomphalaria glabrata snail microbiomes. [PDF]

Parasit Vectors
Nordmeyer SC, Anderson TJC, Le Clec'h W, Chevalier FD.   +3 more
europepmc   +1 more source

Water pollution from swine factory farms poses a threat to endangered and threatened species

Conservation Science and Practice, EarlyView.
Abstract Factory farms, or concentrated animal feeding operations (CAFOs), generate millions of tons of manure each year in the United States. The storage, handling, and land application of this manure leads to air, water, and climate pollution, which disproportionately impacts low‐income communities of color and poses additional public health and ...
Mustafa Saifuddin, Sarah Brickman, Claire S. Huang, Harrison Watson   +3 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source