Results 71 to 80 of about 714,027 (197)

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 2986-3001, September 2026.
Abstract Irinotecan, a topoisomerase I inhibitor, is available as both non‐pegylated and pegylated formulations. The non‐pegylated formulation is licensed for use in advanced colorectal cancer either in combination with other agents or as monotherapy.
Dharmisha Chauhan, Cinzia Dello Russo, Jack Thompson, Dyfrig A. Hughes, Katherine Payne, Maria Tsakiroglou, Paul Ross, Rena Chauhan, Simon Jenkinson, Jessica Keen, Sophie Harding, Eleanor Lau, Michael Braun, Roshan Agarwal, Richard Adams, Elisabeth Rolf, Farah Al‐Sheikhli, Sarah Mitchell, Ruth Hammond, Rosie Roberts, Lorna Cairns, Shirley Heggarty, Janet Graham, Justin Mencel, Munir Pirmohamed   +24 more
wiley   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3002-3011, September 2026.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Classification of High‐ and Low‐Risk Patients With Dermal Leiomyosarcoma: An Exploratory Nationwide Cohort Study

Journal of Surgical Oncology, Volume 134, Issue 3, Page 394-402, September 2026.
ABSTRACT Background Risk factors for dermal leiomyosarcoma (dLMS) metastasis remain poorly defined because methodological constraints, small sample sizes, and short follow‐up have limited previous studies. Objectives To investigate risk factors for metastasis and local recurrence, and to propose a high‐ and low‐risk classification for dLMS. Methods All
Kiya Abebe, Anders Munch, Anne Lene Wagenblast, Grethe Schmidt, David Hebbelstrup Jensen, Michael M. Petersen, Anand C. Loya, Søren Daugaard, Thomas Mentzel, Mikkel Herly, Peter Vester‐Glowinski, Mathias Ørholt   +11 more
wiley   +1 more source

Laryngeal Dysfunction Following COVID‐19: A TriNetX Retrospective Cohort Study

The Laryngoscope, Volume 136, Issue 9, Page 3849-3858, September 2026.
COVID‐19 is associated with an increased incidence of new‐onset laryngeal dysfunction, including chronic cough, dysphagia, voice disorders, vocal fold paralysis, and laryngeal spasm, compared with uninfected controls. Risk peaks one to two years after infection for most outcomes and is influenced by factors such as hospitalization, mechanical ...
Cali Loblundo, Warren B. Chun, Shaun A. Nguyen, Kirsten Meenan, Ashli K. O'Rourke   +4 more
wiley   +1 more source

Redundant Elements in SNOMED CT Concept Definitions [PDF]

, 2013
While redundant elements in SNOMED CT concept definitions are harmless from a logical point of view, they unnecessarily make concept definitions of typically large ontologies such as SNOMED CT hard to construct and to maintain.
Cornet, Ronald, Dentler, Kathrin, Ronald Cornet, Dentler, K., Kathrin Dentler, Cornet, R.   +5 more
core   +1 more source

Recording COVID-19 consultations: review of symptoms, risk factors, and proposed SNOMED CT terms

BJGP Open, 2020
Background: There is an urgent need for epidemiological research in primary care to develop risk assessment processes for patients presenting with COVID-19, but lack of a standardised approach to data collection is a significant barrier to implementation.
Bhautesh Dinesh Jani, Jill P Pell, Dylan McGagh, Harshana Liyanage, Dave Kelly, Simon de Lusignan, Christopher J Weatherburn, Ronnie Burns, Frank M Sullivan, Frances S Mair   +9 more
doaj   +1 more source

Responses to GLP‐1RA in White and Black Adults With Obesity: Insights From Generalized Additive Mixed Models of EHR Data

Obesity, Volume 34, Issue S2, Page 109-118, September 2026.
ABSTRACT Objective This study examined racial differences in weight loss and clinical response to glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) therapy among adults with obesity using real‐world data. Methods We retrospectively analyzed our institution's Research Data Warehouse (RDW) containing deidentified data from electronic health records ...
Jordan H. Mallette, Joshua S. Speed, Seth T. Lirette, Daniel Moore, John S. Clemmer   +4 more
wiley   +1 more source

SNOMED CT -seminaari 12.12.2024 [PDF]

Seminaarin ohjelma. Vain osa esityksistä on saatavilla. • Opening remarks, Juha Mykkänen / THL • eHealth Action Plan and SNOMED CT in Belgium, Project Manager David Op de Beeck, Belgium • SNOMED CT kansallisen jakelukeskuksen ajankohtaiset asiat ...
Op de Beeck, David, Kallio, Markku, Suonpää, Markus, Jalonen, Marko, Kaskinen, Timo, Härkönen, Mikko, Mykkänen, Juha   +6 more
core  

Development of an evidence-based foundation for a Belgian nursing reference set in SNOMED CT

Health Informatics Journal
Objective. To provide a SNOMED CT nursing reference set to exchange unambiguous nursing data across different care settings. Methods. To develop a nursing Reference Set, Standardized Nursing Languages (SNLs) are analyzed and tested for applicability in ...
Jerno Thys, Koen Balcaen, Goele Vanpee, Arabella D’Havé   +3 more
doaj   +1 more source

Recent Advances in Text Anonymization: A Systematic Review

WIREs Data Mining and Knowledge Discovery, Volume 16, Issue 3, September 2026.
This survey presents a unified, cross‐domain overview of text anonymization from 2021 to 2025, covering methods from rule‐based to LLM‐based approaches, relevant datasets, benchmarks, and evaluation strategies. It highlights the critical trade‐off between privacy and utility, underscores the importance of standardizing evaluation protocols and metrics,
Marina Litvak, Alípio Jorge
wiley   +1 more source