Results 171 to 180 of about 423,756 (267)

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz, Pimrapat Gebert, Jingwen Luo, Paraskevi Tassopoulou, Juliane Bolbrinker, Antonios Douros   +5 more
wiley   +1 more source

Genome-Wide SNP Discovery and Population Genomic Characterisation in Indian Major Carp Labeo catla (Hamilton, 1822) Through Low-Depth Whole-Genome Resequencing. [PDF]

Anim Genet
Sahoo B, Nandanpawar P, Das P, Sahoo L, Murmu K, Rasal A, Sundaray JK.   +6 more
europepmc   +1 more source

Characterization of NAT2 Using Long‐Read Sequencing: Allele, Diplotype, and Phenotype Call Accuracy Compared to Other Testing Strategies

Clinical Pharmacology &Therapeutics, EarlyView.
The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John, Erin C. Boone, Byunggil Yoo, Laura B. Ramsey, Andrea Gaedigk   +4 more
wiley   +1 more source

Aberrant one-carbon metabolism and ancestral genetics underlie edematous severe acute malnutrition. [PDF]

Nat Commun
Lie NC, Han Y, Li Q, Jajoo A, Redmond J, Haldipur A, Zewdu S, Banfield E, Swaminathan S, Howell S, Brown O, Sadat R, Hall NJ, Marshall K, Schulze KV, May T, Reid ME, Taylor-Bryan C, Manary MJ, Trehan I, Mbiyavanga M, Akurugu WA, McKenzie CA, Sengupta D, Atkinson EG, Choudhury A, Hanchard NA.   +26 more
europepmc   +1 more source

Triglyceride Polygenic Score Identifies Individuals Who May Respond Differently to Aspirin in Primary Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet, Chenglong Yu, Cammie Tran, Sultana Monira Hussain, Chad A. Bousman, Mark R. Nelson, Andrew M. Tonkin, John J. McNeil, Paul Lacaze   +8 more
wiley   +1 more source

Lung Function-Associated Genetic Variants and Overall Survival in Non-Small Cell Lung Cancer: A Multi-Platform Analysis. [PDF]

Cancer Epidemiol Biomarkers Prev
Li Z, Zhang Z, Zhao YC, Su L, Li Y, Christiani DC.   +5 more
europepmc   +1 more source

Creatinine–Cystatin C Discrepancy and Renal Transporter Polymorphisms in Japanese Patients with Breast Cancer Receiving Abemaciclib

Clinical Pharmacology &Therapeutics, EarlyView.
Abemaciclib increases serum creatinine by inhibiting renal tubular transporters rather than reducing true glomerular filtration rate, a phenomenon known as pseudo‐acute kidney injury. Creatinine–cystatin C discrepancy and genetic determinants of this elevation remain insufficiently characterized in Japanese patients.
Hiroaki Watanabe, Keita Hirai, Takaaki Oba, Mayu Ono, Ken‐ichi Ito, Takafumi Naito   +5 more
wiley   +1 more source

Integrating macro- and meso-level perspectives on school nutrition programs in Dubai: a joint display mixed methods integration study. [PDF]

Front Public Health
AlGurg R, Otaki F, Albloushi K, Al-Sharif GA, Abu Mahfouz N, Paulus A, Khamis A, Alameddine M.   +7 more
europepmc   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

eGFP tagged ZnO nanoparticles from glioblastoma targeting ferroptosis and MRP1 in head and neck squamous cell carcinoma. [PDF]

Discov Nano
Ali S, Li Y, Yotnarong O, Yao C, Zhan Y, Ma R, Shi R, Wang Z, Na R, Tangthong T.   +9 more
europepmc   +1 more source