Results 91 to 100 of about 59,567 (351)

The Role of Differentially Expressed miRNAs and Potential miRNA-mRNA Regulatory Network in Prostate Cancer Progression and Metastasis [PDF]

, 2020
Purpose: Aberrant expression of microRNAs (miRNAs) has been discovered in prostate cancer progression however their function is not well understood, thereby further investigation is required to understand the importance of underlying mechanisms and their
Arisan, E.D., Arisan, E.D., Freitas, I.L., Freitas, I.L., Pazoki, K., Pazoki, K., Rahim, S., Rahim, S., Uysal Onganer, P., Uysal Onganer, P.   +9 more
core   +1 more source

Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1

Nucleic Acids Research, 2018
Post-transcriptional modification of snRNA is central to spliceosome function. Usb1 is an exoribonuclease that shortens the oligo-uridine tail of U6 snRNA, resulting in a terminal 2′,3′ cyclic phosphate group in most eukaryotes, including humans. Loss of
Y. Nomura, Daniel Roston, E. Montemayor, Q. Cui, S. Butcher   +4 more
semanticscholar   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

A role for the C. elegans Argonaute protein CSR-1 in small nuclear RNA 3' processing.

PLoS Genetics
The Integrator is a multi-subunit protein complex that catalyzes the maturation of snRNA transcripts via 3' cleavage, a step required for snRNA incorporation with snRNP for spliceosome biogenesis. Here we developed a GFP based in vivo snRNA misprocessing
Brandon M Waddell, Cheng-Wei Wu
doaj   +1 more source

Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat. [PDF]

PLoS Pathogens, 2010
The human immunodeficiency virus 1 (HIV-1) transcriptional transactivator (Tat) is essential for synthesis of full-length transcripts from the integrated viral genome by RNA polymerase II (Pol II).
Lisa Muniz, Sylvain Egloff, Bettina Ughy, Beáta E Jády, Tamás Kiss   +4 more
doaj   +1 more source

Template-dependent multiple displacement amplification for profiling human circulating RNA [PDF]

, 2017
Multiple displacement amplification (MDA) is widely used in whole-genome/transcriptome amplification. However, template-independent amplification (TIA) in MDA is a commonly observed phenomenon, particularly when using high concentrations of random ...
Crosby, Seth D, Di Bisceglie, Adrian M, Fan, Xiaofeng, Lu, Yang, Ren, Yi, Wang, Weihua, Xu, Yuan   +6 more
core   +2 more sources

Differential long-term stability of microRNAs and RNU6B snRNA in 12–20 year old archived formalin-fixed paraffin-embedded specimens

BMC Cancer, 2017
The quantitative analysis of microRNA (miRNA) gene expression in archived formalin-fixed, paraffin embedded (FFPE) tissues has been instrumental to identifying their potential roles in cancer biology, diagnosis, and prognosis. However, it remains unclear
S. Peskoe, J. Barber, Qizhi Zheng, A. Meeker, A. D. De Marzo, E. Platz, Shawn E Lupold   +6 more
semanticscholar   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

eLife, 2015
Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding ...
Sunbin Liu, Sina Mozaffari-Jovin, Jan Wollenhaupt, Karine F Santos, Matthias Theuser, Stanislaw Dunin-Horkawicz, Patrizia Fabrizio, Janusz M Bujnicki, Reinhard Lührmann, Markus C Wahl   +9 more
doaj   +1 more source

Pre-mRNA splicing is a determinant of nucleosome organization. [PDF]

PLoS ONE, 2013
Chromatin organization affects alternative splicing and previous studies have shown that exons have increased nucleosome occupancy compared with their flanking introns. To determine whether alternative splicing affects chromatin organization we developed
Hadas Keren-Shaul, Galit Lev-Maor, Gil Ast   +2 more
doaj   +1 more source