Results 111 to 120 of about 59,567 (351)

Nuclear Pre-snRNA Export Is an Essential Quality Assurance Mechanism for Functional Spliceosomes

Cell Reports, 2019
Summary: Removal of introns from pre-mRNAs is an essential step in eukaryotic gene expression, mediated by spliceosomes that contain snRNAs as key components. Although snRNAs are transcribed in the nucleus and function in the same compartment, all except
Daniel Becker, Anna Greta Hirsch, Lysann Bender, Thomas Lingner, Gabriela Salinas, Heike Krebber   +5 more
doaj   +1 more source

Protein-RNA interactions: a structural analysis [PDF]

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Berman, HM, Daley, DT, Jones, S, Luscombe, NM, Thornton, JM   +4 more
core   +2 more sources

Biallelic Mutations in the 3’ Exonuclease TOE1 Cause Pontocerebellar Hypoplasia and Uncover a Role in snRNA Processing

Nature Genetics, 2016
Deadenylases are best known for degrading the poly(A) tail during mRNA decay. The deadenylase family has expanded throughout evolution and, in mammals, consists of 12 Mg2+-dependent 3′-end RNases with substrate specificity that is mostly unknown ...
Rea M. Lardelli, A. Schaffer, V. Eggens, M. Zaki, Stephanie Grainger, S. Sathe, Eric L. Van Nostrand, Zinayida Schlachetzki, Başak Rosti, N. Akizu, Eric Scott, J. Silhavy, Laura D. Heckman, R. O. Rosti, E. Dikoglu, A. Gregor, Alicia Guemez-Gamboa, D. Musaev, R. Mande, A. Widjaja, Tim L Shaw, Sebastian J. Markmiller, I. Marín-Valencia, J. Davies, L. de Meirleir, H. Kayserili, U. Altunoğlu, M. Freckmann, L. Warwick, D. Chitayat, S. Blaser, A. Çağlayan, K. Bilguvar, H. Per, C. Fagerberg, H. Christesen, M. Kibaek, K. Aldinger, D. Manchester, N. Matsumoto, K. Muramatsu, H. Saitsu, M. Shiina, K. Ogata, N. Foulds, W. Dobyns, N. Chi, D. Traver, L. Spaccini, S. Bova, S. Gabriel, M. Gunel, E. Valente, M. Nassogne, E. Bennett, Gene W. Yeo, F. Baas, J. Lykke-Andersen, J. Gleeson   +58 more
semanticscholar   +1 more source

A positive feedback circuit between RN7SK snRNA and m6A readers is essential for tumorigenesis [PDF]

, 2022
Xin Xu, Lifang Ma, Xiao Zhang, Susu Guo, Wanxin Guo, Yikun Wang, Shiyu Qiu, Xiaoting Tian, Yayou Miao, Yongchun Yu, Jiayi Wang   +10 more
openalex   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Chemical Synthesis of U1 snRNA Derivatives

Organic Letters, 2013
U1 snRNA is an interesting biological tool for splicing correction and regulation of gene expression. However, U1 snRNA has never been chemically synthesized. In this study, the first chemical synthesis of U1snRNA and its analogues was carried out. Moreover, it was found that the binding affinity of the modified U1 snRNA with an ethylene glycol linkage
A. Ohkubo, Y. Kondo, M. Suzuki, H. Kobayashi, T. Kanamori, Y. Masaki, K. Seio, K. Nagai, M. Sekine   +8 more
openaire   +2 more sources

The conserved 3′ end domain of U6atac snRNA can direct U6 snRNA to the minor spliceosome [PDF]

RNA, 2009
U6 and U6atac snRNAs play analogous critical roles in the major U2-dependent and minor U12-dependent spliceosomes, respectively. Previous results have shown that most of the functional cores of these two snRNAs are either highly similar in sequence or functionally interchangeable.
Rosemary C, Dietrich, Richard A, Padgett, Girish C, Shukla   +2 more
openaire   +2 more sources

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA

Cell Discovery, 2016
The DNA damage response involves coordinated control of gene expression and DNA repair. Using deep sequencing, we found widespread changes of alternative cleavage and polyadenylation site usage on ultraviolet-treatment in mammalian cells.
E. Devany, Ji Yeon Park, Michael R. Murphy, George Zakusilo, Jorge Baquero, Xiaokan Zhang, M. Hoque, B. Tian, F. Kleiman   +8 more
semanticscholar   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source