Results 11 to 20 of about 59,567 (351)
U5 snRNA Interactions With Exons Ensure Splicing Precision [PDF]
Frontiers in Genetics, 2021 Imperfect conservation of human pre-mRNA splice sites is necessary to produce alternative isoforms. This flexibility is combined with the precision of the message reading frame.
Olga V. Artemyeva-Isman +1 more
doaj +2 more sources
Journal of Molecular Evolution, 2008 7SK RNA is a highly abundant noncoding RNA in mammalian cells whose function in transcriptional regulation has only recently been elucidated. Despite its highly conserved sequence throughout vertebrates, all attempts to discover 7SK RNA homologues in invertebrate species have failed so far.
Gruber, Andreas R. +9 more
openaire +5 more sources
Perspectives on single-nucleus RNA sequencing in different cell types and tissues [PDF]
Journal of Pathology and Translational Medicine, 2023 Single-cell RNA sequencing has become a powerful and essential tool for delineating cellular diversity in normal tissues and alterations in disease states.
Nayoung Kim +4 more
doaj +1 more source
Pre-mRNA splicing-associated diseases and therapies
RNA Biology, 2023 Precursor mRNA (pre-mRNA) splicing is an essential step in human gene expression and is carried out by a large macromolecular machine called the spliceosome.
Sierra L. Love +3 more
doaj +1 more source
The role of FRUITFULL controlling cell cycle during early flower development revealed by time-series snRNA-seq experiments. [PDF]
Genome BiolChen P +7 more
europepmc +3 more sources
U2.3 Precursor Small Nuclear RNA in vitro Processing Assay
Bio-Protocol, 2021 Small nuclear RNAs (snRNAs) are vital for eukaryotic cell activities and play important roles in pre-mRNA splicing. The molecular mechanism underlying the transcription of snRNA, regulated via upstream/downstream cis-elements and relevant trans-elements,
Chan Lin +5 more
doaj +1 more source
Mechanism of U6 snRNA oligouridylation by human TUT1
Nature Communications, 2023 U6 snRNA is a catalytic RNA responsible for pre-mRNA splicing reactions and undergoes various post-transcriptional modifications during its maturation process.
Seisuke Yamashita, Kozo Tomita
doaj +1 more source
Conditional U1 gene silencing in Toxoplasma gondii [PDF]
, 2015 The functional characterisation of essential genes in apicomplexan parasites, such as Toxoplasma gondii or Plasmodium falciparum, relies on conditional mutagenesis systems. Here we present a novel strategy based on U1 snRNP-mediated gene silencing.
Blackman, Michael J. +10 more
core +19 more sources
Human spliceosomal snRNA sequence variants generate variant spliceosomes
RNA: A publication of the RNA Society, 2021 Human pre-mRNA splicing is primarily catalyzed by the major spliceosome, comprising five small nuclear ribonucleoprotein complexes, U1, U2, U4, U5, and U6 snRNPs, each of which contains the corresponding U-rich snRNA.
Justin W. Mabin +3 more
semanticscholar +1 more source
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
Nature, 2020 Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite) 1 . It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary ...
Wenfei Sun +17 more
semanticscholar +1 more source