Results 271 to 280 of about 59,567 (351)

Generation of functional noncanonical donor splice sites by +2T variants in breast cancer susceptibility genes: impact on clinical interpretation

The Journal of Pathology, Volume 268, Issue 2, Page 150-163, February 2026.
Abstract Splicing dysregulation is a relevant mechanism of pathogenicity for variants in disease susceptibility genes. Variants affecting the critical intronic +1 and +2 GT nucleotides of the 5’ splice sites (5'ss) are generally strong indicators of pathogenicity.
Inés Llinares‐Burguet, Lara Sanoguera‐Miralles, Elena Bueno‐Martínez, Alicia García‐Álvarez, Alberto Valenzuela‐Palomo, Pedro Pérez‐Segura, Miguel de la Hoya, Eladio A Velasco‐Sampedro   +7 more
wiley   +1 more source

Heterogeneity of human U snRNAs [PDF]

Nucleic Acids Research, 1988
openaire   +1 more source

PitNET tissue deconvolution: tracing normal tissue residues and immune dynamics. [PDF]

Front Endocrinol (Lausanne)
Dalle Nogare M, Avallone S, Picello L, Puggina D, Denaro L, Sales G, Vazza G, Occhi G.   +7 more
europepmc   +1 more source

Mutation-adapted U1 snRNA corrects a splicing error of the dopa decarboxylase gene.

Human Molecular Genetics, 2016
Ni‐Chung Lee, Yu‐may Lee, Pin-Wen Chen, B. Byrne, W. Hwu   +4 more
semanticscholar   +1 more source

ETS Variant Transcription Factor 6 Promotes Glucose Metabolism Reprogramming in HCC

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Glucose metabolic reprogramming is a key hallmark of tumour cells, and the designed inhibitors targeting tumour glucose metabolism reprogramming may serve as an effective therapeutic strategy. The ETS Variant Transcription Factor 6 (ETV6) is a potent transcriptional repressor strongly associated with tumorgenesis. However, the precise role and
Chunmei Guo, Lingqian Xie, Huiqing Yin, Lina Yi, Lin Jin, Xiangwei Liu, Qingqing Zhang, Zijian Li, Shuqing Liu, Ming‐Zhong Sun   +9 more
wiley   +1 more source

MAPK14 converges on key transcriptional machinery to promote vascular smooth muscle cell degeneration in abdominal aortic aneurysm. [PDF]

Signal Transduct Target Ther
Wu X, Wang C, Ishimwe N, Zhang W, Doja J, Shan S, Ge C, Sun Y, Zhao J, Castillo M, Sotonyi P, Gyurok G, Csanyi G, Bryant WB, Dong K, Chen Y, Vazquez-Padron R, Miano JM, Long X.   +18 more
europepmc   +1 more source

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

Yingxue Li, Changxiang Huan, Haoting Sun, Wei Zhang, Zhenzhong Guo, Chuanyu Li, Jia Yao, Zhiqi Zhang, Shizhe Yu, Qiongzhu Dong, Lun–Xiu Qin, Jinze Li, Lianqun Zhou   +12 more
openalex   +1 more source

An Improved Description of the Small RNA Landscape of the Human Fungal Pathogen Aspergillus fumigatus

Molecular Microbiology, Volume 125, Issue 2, Page 133-144, February 2026.
The mechanisms of small RNA biogenesis in fungi are diverse and multifactorial. Here, we provide an improved understanding of the processing of double‐stranded RNA in the human fungal pathogen Aspergillus fumigatus, revealing susceptibility to high levels of double‐stranded RNA and limited input of the canonical RNAi machinery on the endogenous small ...
Xiaoqing Pan, Abdulrahman A. Kelani, Lukas Schrettenbrunner, Swatika Prabakar, Bhawana Israni, Matthew G. Blango   +5 more
wiley   +1 more source

Spatial Transcriptomic Characteristics of the Aging Human Ovary. [PDF]

Aging Cell
Zhang M, Guo F, Zhang Q, Hu Q, Sun D, Ma Y, Li Y, Guo M, Ding H, Guo Y, Yang B, Li S, Sun N, Zheng Y, Li W.   +14 more
europepmc   +1 more source

Vielseitiger und selektiver Biomolekül‐Pulldown mit kombinatorischen DNA‐quervernetzten Polymeren

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Wir stellen ein programmierbares Polymersystem für die universelle, sequenzselektive Bioseparation unter nativen Bedingungen vor. Eine Polymerphasentrennung wird durch kombinatorische DNA‐Vernetzung erreicht, wodurch DNA, RNA oder Proteine in homogener Lösung mit hoher Pulldown‐Effizienz und vernachlässigbarer Hintergrundbindung eingefangen werden ...
Sarah K. Speed, Krishna Gupta, Yu‐Hsuan Peng, Elisha Krieg   +3 more
wiley   +1 more source