Results 21 to 30 of about 59,567 (351)
U7 snRNA: A tool for gene therapy
Journal of Gene Medicine, 2021 Most U‐rich small nuclear ribonucleoproteins (snRNPs) are complexes that mediate the splicing of pre‐mRNAs. U7 snRNP is an exception in that it is not involved in splicing but is a key factor in the unique 3′ end processing of replication‐dependent ...
Ankur Gadgil, K. Raczyńska
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Ophthalmology Science, 2023 Purpose: Proliferative vitreoretinopathy (PVR) is the most common cause of failure of retinal reattachment surgery, and the molecular changes leading to this aberrant wound healing process are currently unknown.
Clayton P. Santiago, PhD, MS +8 more
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Nature Communications, 2021 The U6 snRNA, the core catalytic component of the spliceosome, is extensively modified post-transcriptionally, with 2’-O-methylation being most common. However, how U6 2’-O-methylation is regulated remains largely unknown. Here we report that TFIP11, the
A. Duchemin +14 more
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Pseudouridines in spliceosomal snRNAs [PDF]
Protein & Cell, 2011 Spliceosomal RNAs are a family of small nuclear RNAs (snRNAs) that are essential for pre-mRNA splicing. All vertebrate spliceosomal snRNAs are extensively pseudouridylated after transcription. Pseudouridines in spliceosomal snRNAs are generally clustered in regions that are functionally important during splicing.
Andrew T, Yu, Junhui, Ge, Yi-Tao, Yu
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Pseudouridine modification in Caenorhabditis elegans spliceosomal snRNAs: unique modifications are found in regions involved in snRNA-snRNA interactions [PDF]
BMC Molecular Biology, 2005 AbstractBackgroundPseudouridine (Ψ) is an abundant modified nucleoside in RNA and a number of studies have shown that the presence of Ψ affects RNA structure and function. The positions of Ψ in spliceosomal small nuclear RNAs (snRNAs) have been determined for a number of species but not for the snRNAs fromCaenorhabditis elegans(C.
Patton, Jeffrey R, Padgett, Richard W
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The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression [PDF]
EMBO Journal, 2017 Sylvain Egloff +5 more
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SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs [PDF]
, 1990 SSB-1, the yeast single-strand RNA-binding protein, is demonstrated to be a yeast nucleolar-specific, silver-binding protein. In double-label immunofluorescence microscopy experiments antibodies to two other nucleolar proteins, RNA Pol I 190-kD and ...
Abelson, John +3 more
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Mechanistic insights into m6A modification of U6 snRNA by human METTL16
Nucleic Acids Research, 2020 The N6-methyladenosine modification at position 43 (m6A43) of U6 snRNA is catalyzed by METTL16, and is important for the 5′-splice site recognition by U6 snRNA during pre-mRNA splicing.
T. Aoyama, S. Yamashita, K. Tomita
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Genome Medicine, 2023 Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo.
Randy B. Kang +9 more
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Recent advances in deciphering hippocampus complexity using single-cell transcriptomics
Neurobiology of Disease, 2023 Single-cell and single-nucleus RNA sequencing (scRNA-seq and snRNA-seq) technologies have emerged as revolutionary and powerful tools, which have helped in achieving significant progress in biomedical research over the last decade.
Chenxu Chang, Hongyan Zuo, Yang Li
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