Results 321 to 330 of about 59,567 (351)

U7 snRNA, a Small RNA with a Big Impact in Gene Therapy

Human Gene Therapy, 2021
The uridine-rich 7 (U7) small nuclear RNA (snRNA) is a component of a small nuclear ribonucleoprotein (snRNP) complex. U7 snRNA naturally contains an antisense sequence that identifies histone premessenger RNAs (pre-mRNAs) and is involved in their 3′ end
Daniel Lesman, Yacidzohara Rodríguez, D. Rajakumar, N. Wein   +3 more
semanticscholar   +1 more source

The nucleolar snRNAs: catching up with the spliceosomal snRNAs

Trends in Biochemical Sciences, 1993
Despite their early discovery, research into the small RNAs associated with the eukaryotic nucleolus (snoRNAs) has lagged behind that of their cousins, the small nuclear RNAs which are known to function in mRNA splicing (spliceosomal snRNAs). Recent progress has now shown that the snoRNAs also occupy a vital niche in the RNA world, participating in the
M J, Fournier, E S, Maxwell
openaire   +2 more sources

De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

Nature
Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed after comprehensive genetic testing, primarily of protein-coding genes1.
Yuyang Chen, R. Dawes, Hyung Chul Kim, A. Ljungdahl, S. Stenton, Susan Walker, Jenny Lord, G. Lemire, Alexandra C. Martin-Geary, Vijay S. Ganesh, Jialan Ma, J. Ellingford, E. Delage, Elston N. D’Souza, Shan Dong, David R. Adams, Kirsten Allan, Madhura Bakshi, Erin E. Baldwin, S. Berger, Jonathan A. Bernstein, Ishita Bhatnagar, E. Blair, Natasha J. Brown, Lindsay C Burrage, Kimberly Chapman, D. Coman, A. Compton, C. Cunningham, Precilla D’Souza, P. Danecek, Emmanuèle C. Délot, Kerith-Rae Dias, Ellen R Elias, F. Elmslie, Carey-Anne Evans, Lisa J Ewans, Kimberly M Ezell, Jamie L Fraser, L. Gallacher, C. Genetti, A. Goriely, Christina L. Grant, Tobias B. Haack, Jenny Higgs, A. Hinch, M. Hurles, Alma Kuechler, Katherine L. Lachlan, S. Lalani, F. Lecoquierre, E. Leitão, A. L. Fevre, R. Leventer, J. Liebelt, S. Lindsay, Paul J. Lockhart, Alan S. Ma, Ellen F. Macnamara, Sahar Mansour, Taylor M. Maurer, Hector R. Mendez, Kay Metcalfe, Stephen B. Montgomery, M. Moosajee, M. Nassogne, Serena Neumann, Michael O'Donoghue, Melanie O’Leary, E. Palmer, Nikhil Pattani, John A. Phillips, Georgia Pitsava, Ryan Pysar, Heidi L. Rehm, Chloe M Reuter, N. Revencu, A. Riess, R. Rius, Lance Rodan, T. Roscioli, Jill A. Rosenfeld, R. Sachdev, C. Shaw-Smith, Cas Simons, S. Sisodiya, Penny Snell, Laura St Clair, Zornitza Stark, Helen Stewart, T. Tan, Natalie B. Tan, Suzanna E. L. Temple, D. Thorburn, C. Tifft, E. Uebergang, G. VanNoy, Pradeep Vasudevan, Eric Vilain, D. Viskochil, L. Wedd, M. Wheeler, Susan M. White, Monica Wojcik, Lynne A Wolfe, Zoe Wolfenson, Caroline F. Wright, Changrui Xiao, David Zocche, J. L. Rubenstein, Eirene Markenscoff-Papadimitriou, S. Fica, D. Baralle, C. Depienne, D. MacArthur, Joanna M M Howson, Stephan J. Sanders, A. O’Donnell-Luria, N. Whiffin   +118 more
semanticscholar   +1 more source

Drosophila melanogaster U1 snRNA genes

Journal of Molecular Biology, 1984
We have isolated and characterized a recombinant which contains a Drosophila melanogaster U1 small nuclear RNA (snRNA) gene colinear with the published snRNA sequence. Southern hybridizations of the fly genomic DNA, using as probe a plasmid containing only the coding region of the gene, shows that the fly contains at most three or four genes and very ...
A, Alonso, J L, Jorcano, E, Beck, B, Hovemann, T, Schmidt   +4 more
openaire   +2 more sources

Characterization of snRNA and snRNA-type genes in the pufferfish Fugu rubripes

Gene, 2004
Vertebrate snRNA and snRNA-type genes occur in independent transcription units with external promoters. The transcription level from the basal promoter is enhanced by the distal sequence element DSE. This element contains almost invariably two activator submotifs, the Staf binding site and the octamer motif, recruiting the Staf and Oct-1 ...
Evelyne, Myslinski, Alain, Krol, Philippe, Carbon   +2 more
openaire   +3 more sources

SnRNAs, SnRNPs, and RNA Processing

Annual Review of Biochemistry, 1982
PERSPECTIVES AND SUMMARY . SMALL RNAs . Historical Aspects . Conservation Through Evolution . Synthesis 0/ Small RNAs ..
H, Busch, R, Reddy, L, Rothblum, Y C, Choi   +3 more
openaire   +2 more sources

U6 snRNA Maturation and Stability

Experimental Cell Research, 1996
The U6 snRNP is found as a monomer and as a heterodimer, complexed with the U4 snRNP (U4/U6). Northern blotting detects approximately equal amounts of U4/U6 heterodimer and U6 monomer in the nucleus but only U6 monomer in bona fide cytoplasm. In mammalian cells, newly synthesized U6 appears transiently in the cytoplasm before returning to the nucleus ...
M G, Fury, G W, Zieve
openaire   +2 more sources

Formation of the 3′ end of U1 snRNA requires compatible snRNA promoter elements

Cell, 1986
U1 and U2 snRNAs are thought to be transcribed by RNA polymerase II. A conserved sequence known as the 3' box is located just downstream from the snRNA coding region and directs formation of the 3' end of pre-U1 and pre-U2 snRNA. We show here that a U1 or U2 promoter containing an intact snRNA enhancer is required for the U1 3' box to function ...
N, Hernandez, A M, Weiner
openaire   +2 more sources

Substoichiometric ribose methylations in spliceosomal snRNAs

Organic & Biomolecular Chemistry, 2017
Sequencing-based profiling of spliceosomal snRNA demonstrates substoichiometric methylation at cap-proximal and internal sites that may impact splicing and protein production.
Nicolai Krogh, Martin Kongsbak-Wismann, Carsten Geisler, Henrik Nielsen   +3 more
openaire   +3 more sources

Cytoplasmic maturation of the snRNAs

Journal of Cellular Physiology, 1987
AbstractThe snRNAs are abundant and stable components of the interphase nucleus. Aqueous and non‐aqueous cell fractionation demonstrate that the snRNAs appear transiently in the cytoplasm shortly after transcription, before returning permanently to the interphase nucleus.
openaire   +2 more sources