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3′ end formation of U1 snRNA precursors is coupled to transcription from snRNA promoters
Cell, 1986Promoters of small nuclear RNA (snRNA) genes are partly responsible for 3' end formation of snRNA precursors. In injected X. laevis oocytes, substitution of an mRNA promoter (HSV tk) for the snRNA promoter significantly reduces the utilization of a conserved snRNA 3' end signal and permits recognition of a downstream polyadenylation site.
H E, de Vegvar, E, Lund, J E, Dahlberg
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Journal of Molecular Biology, 1991
We have identified and characterized the full set of spliceosomal small nuclear RNAs (snRNAs; U1, U2, U4, U5 and U6) from the ciliated protozoan Tetrahymena thermophila. With the exception of U4 snRNA, the sizes of the T. thermophila snRNAs are closely similar to their metazoan homologues. The T.
Orum, H, Nielsen, Henrik, Engberg, J
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We have identified and characterized the full set of spliceosomal small nuclear RNAs (snRNAs; U1, U2, U4, U5 and U6) from the ciliated protozoan Tetrahymena thermophila. With the exception of U4 snRNA, the sizes of the T. thermophila snRNAs are closely similar to their metazoan homologues. The T.
Orum, H, Nielsen, Henrik, Engberg, J
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Science, 2011
Covalent addition of methyl groups regulates the function of a number of proteins, including histones. The carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) is made up of 7-mer repeats, and their site-specific phosphorylation results in the recruitment of regulators to the transcription complex. Sims et al. (p.
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Covalent addition of methyl groups regulates the function of a number of proteins, including histones. The carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) is made up of 7-mer repeats, and their site-specific phosphorylation results in the recruitment of regulators to the transcription complex. Sims et al. (p.
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Splicing-related catalysis by protein-free snRNAs
Nature, 2001Removal of intervening sequences from eukaryotic messenger RNA precursors is carried out by the spliceosome, a complex assembly of five small nuclear RNAs (snRNAs) and a large number of proteins. Although it has been suggested that the spliceosome might be an RNA enzyme, direct evidence for this has been lacking, and the identity of the catalytic ...
S, Valadkhan, J L, Manley
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1981
The work of our laboratory in 1962 led to the evolution of methods for isolation of nucleoli (Busch and Smetana 1970). In the course of these studies it became apparent that the nucleoli were very complex structures that contained a variety of enzymes, nonhistone proteins, the rDNA and precursors of rRNA.
H. Busch +3 more
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The work of our laboratory in 1962 led to the evolution of methods for isolation of nucleoli (Busch and Smetana 1970). In the course of these studies it became apparent that the nucleoli were very complex structures that contained a variety of enzymes, nonhistone proteins, the rDNA and precursors of rRNA.
H. Busch +3 more
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The increasing functional repertoire of U1 snRNA
Biochemical Society Transactions, 2012Splicing is a key process for mRNA maturation, particularly in higher eukaryotes where most protein-coding transcripts contain multiple introns. It is achieved by the concerted action of five snRNAs (small nuclear RNAs) and hundreds of accessory proteins that form the spliceosome.
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U-snRNA genes, U-snRNAs and U-snRNPs of higher plants
Molecular Biology Reports, 1990W, Filipowicz +3 more
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The Role of snRNAs in Spliceosomal Catalysis
2013The spliceosomes, large ribonucleoprotein (RNP) assemblies that remove the intervening sequences from pre-mRNAs, contain a large number of proteins and five small nuclear RNAs (snRNAs). One snRNA, U6, contains highly conserved sequences that are thought to be the functional counterparts of the RNA elements that form the active site of self-splicing ...
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