Results 81 to 90 of about 59,567 (351)
Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells [PDF]
, 2009 Dr1 (also known as NC2{beta}) was identified as a repressor of RNA polymerase (pol) II transcription. It was subsequently shown to inhibit pol III transcription when expressed at high levels in vitro or in yeast cells.
Albert +51 more
core +6 more sources
Expanding the CRISPR toolbox in Culicine mosquitoes: in vitro validation of Pol III promoters [PDF]
, 2020 CRISPR–Cas9-based “gene drive” technologies have been proposed as a novel and effective means of controlling human diseases vectored by mosquitoes. However, more complex designs than those demonstrated to date—and an expanded molecular toolbox with which
Alphey, Luke +6 more
core +1 more source
Crystal structures of U6 snRNA-specific terminal uridylyltransferase
Nature Communications, 2017 The terminal uridylyltransferase, TUT1, builds or repairs the 3′-oligo-uridylylated tail of U6 snRNA. The 3′-oligo-uridylylated tail is the Lsm-binding site for U4/U6 di-snRNP formation and U6 snRNA recycling for pre-mRNA splicing.
S. Yamashita +3 more
semanticscholar +1 more source
Characterization of U6 snRNA–protein interactions
RNA, 1999 Through a combination of in vitro snRNP reconstitution, photocross-linking and immunoprecipitation techniques, we have investigated the interaction of proteins with the spliceosomal U6 snRNA in U6 snRNPs, U4/U6 di-snRNPs and U4/U6.U5 tri-snRNPs. Of the seven Lsm (Sm-like) proteins that associate specifically with this spliceosomal snRNA, three were ...
Vidal VPI, Verdone L, Mayes AE, Beggs JD
openaire +4 more sources
Advanced Science, EarlyView.Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren +9 more
wiley +1 more source
PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle [PDF]
, 1989 The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive temperatures. We have sequenced the PRP4 gene and shown that it encodes a 52-kilodalton protein.
Abelson, John N., Banroques, Josette
core +1 more source
Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA
Nature Communications, 2018 The spliceosome removes introns from precursor messenger RNA (pre-mRNA) to produce mature mRNA. Prior to catalysis, spliceosomes are assembled de novo onto pre-mRNA substrates.
E. Montemayor +5 more
semanticscholar +1 more source
WU sn-prep Protocol for Solid Tumors - snRNA protocol v2.8 v1 [PDF]
, 2022 Wagma Caravan +2 more
openalex +1 more source
Suppressor U1 snRNAs in Drosophila. [PDF]
Genetics, 1994 Abstract Although the role of U1 small nuclear RNAs (snRNAs) in 5' splice site recognition is well established, suppressor U1 snRNAs active in intact multicellular animals have been lacking. Here we describe suppression of a 5' splice site mutation in the Drosophila melanogaster white gene (wDR18) by compensatory changes in U1 snRNA ...
P C, Lo, D, Roy, S M, Mount
openaire +2 more sources
Advanced Science, EarlyView.Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu +17 more
wiley +1 more source