Results 131 to 140 of about 42,421 (197)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

[The Official Program of Family and Community Medicine has not changed so that everything remains the same]. [PDF]

Aten Primaria
Vázquez Díaz JR, García Hernández M.
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, Volume 36, Issue 4, July 2026.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Mode localization in chiral periodic approximants of Fibonacci magnonic superlattices. [PDF]

Sci Rep
Flores-Farías J, Contreras-Gallardo P, Brevis F, Vidal-Silva N, Landeros P, Arias R, Gallardo RA.   +6 more
europepmc   +1 more source

Patch Test Results With the European Baseline Series, 2021/2022—Joint European Results of the ESSCAA and the EBSB Working Groups of the ESCD, and the GEIDACC

Contact Dermatitis, Volume 95, Issue 1, Page 17-32, July 2026.
ABSTRACT Background Patch test results obtained with the European Baseline Series (EBS) in its current version serve both contact allergy surveillance and (re‐)assessing the diagnostic value of EBS allergens. Objectives To present results of current EBS patch testing, obtained in 59 departments in 14 European countries during 2021 and 2022.
Wolfgang Uter, S. Mark Wilkinson, Olivier Aerts, Andrea Bauer, Leopoldo Borrego, Richard Brans, Timo Buhl, Heinrich Dickel, Aleksandra Dugonik, Francesca Larese Filon, Ana Giménez Arnau, Cataldo Patruno, Györgyi Pónyai, Stamatis Gregoriou, Steffen Schubert, Dagmar Simon, Luca Stingeni, Skaidra Valiukevičienė, Elke Weisshaar, Thomas Werfel, Margarida Gonçalo, Marie‐L. A. Schuttelaar, ESSCAA and EBSB ESCD Working Groups, and the GEIDACC , Birger Kränke, Alexander Navarini, Philip Spring, Ulrike Beiteke, Cecilia Dietrich, Sibylle Schliemann, Detlef Becker, Swen Malte John, Nicola Wagner, Dimitra Koumaki, Maddalena Napolitano, Anna Belloni Fortina, Francesca Larese Filon, Rosella Gallo, Thomas Rustemeyer, Radoslaw Spiewak, Maja Kalac Pandurovic, Tanja Kmecl, Mojca Simončič Godnič, Nada Kecelj, Philippa Cousen, Ella Dendooven, Juan Francisco Silvestre Salvador, José Manuel Carrascosa Carrillo, Mónica Munera Campos, Esther Serra Baldrich, Gemma Melé‐Ninot, Cristina Barrabés Torrella, David Pesqué, María Antonia Pastor Nieto, Francisco Navarro Triviño, Inmaculada Ruiz Gonzales, Enrique Gómez de la Fuente, Susana Córdoba Guijarro, Francisco Javier Ortiz de Frutos, Fátima Tous Romero, Tatiana Sanz Sánchez, Pablo Chicharro Manso, Marta Andreu Barasoain, Marta Elosua González, Araceli Sánchez Gilo, Paloma Sánchez‐Pedreño Guillén, Pedro Mercader‐García, Carmen Paredes Suárez, María Elena Gatica Ortega, José Juan Pereyra Rodríguez, Javier Miquel Miquel, Mercedes Rodríguez Serna, Violeta Zaragoza Ninet, Ricardo González Pérez   +73 more
wiley   +1 more source

Evaluation of the exposure-response relationship of pembrolizumab in non-small cell lung cancer: observational study protocol in real-world clinical practice. [PDF]

BMC Cancer
Vázquez-Quiroga S, García-Martínez S, Jiménez-Meseguer M, Irusta-Gonzalo A, Jáñez-Carrera R, Otero-Espinar FJ, Ruiz-Martín G, García-Díaz B, López-Martín A, Peña-Cabia S.   +9 more
europepmc   +1 more source

LLM‐Assisted Topic Modelling for Hate Speech Characterization

Expert Systems, Volume 43, Issue 7, July 2026.
ABSTRACT In the digital era, the internet and social media have transformed communication but have also facilitated the spread of hate speech and disinformation, leading to radicalization, polarisation and toxicity. This is especially concerning for media outlets due to their significant role in shaping public discourse. This study examines the topics,
Alejandro Buitrago López, Javier Pastor‐Galindo, José A. Ruipérez‐Valiente   +2 more
wiley   +1 more source

SEOM-GEMCAD-TTD clinical guidelines for anal cancer (2025). [PDF]

Clin Transl Oncol
Morales MG, Montes AF, Fernández-Plana J, Cañete IG, Raga MG, Jiménez-Castro J, Martel IJ, Santasusana JM, Marqués EP, Gómez-España MA.   +9 more
europepmc   +1 more source

How Context Shapes Person‐Centred Fundamental Care Through Nurse–Patient Relationships: Validation of the FoC Intelligence Modelling Tool and Predictive Pathway Analysis

Journal of Advanced Nursing, Volume 82, Issue 7, Page 7200-7210, July 2026.
ABSTRACT Background The Fundamentals of Care (FoC) Framework emphasises that care quality depends not only on clinical tasks but also on interpersonal relationships and the organisational context in which care is delivered. Although patient‐reported outcome and experience measures (PROMs and PREMs) have gained relevance in capturing these aspects ...
Regina Allande‐Cussó, Maria Alejandra Pinero de Plaza, Alison Kitson, Rebecca Feo, Tiffany Conroy, Ana María Porcel‐Gálvez   +5 more
wiley   +1 more source

The effect of an educational intervention and an app-based outdoor air pollution alert system in reducing exacerbations in patients with COPD. [PDF]

BMC Prim Care
Vicente-García T, Maderuelo-Fernández JA, Marcos-Romero I, Herrero-Hernández B, Conde-Martín S, Rodríguez-Sánchez E, Gómez-Marcos MA, Garcia-Ortiz L, Lugones-Sánchez C.   +8 more
europepmc   +1 more source