Results 101 to 110 of about 623,753 (303)
What's wrong with science? [PDF]
, 2009 Here is an idea that might help save the world. It is that science, properly understood, provides us with the methodological key to the salvation of humanity.
Maxwell, N
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Conditions d’émergence et enjeux des communs scientifiques à partir d’une expérimentation lyonnaise
Tic & Société, 2018 The article highlights the intellectual filiations and the issues surrounding scientific commons, characterized by activities of collectively managing and sustaining information resources resulting from the research practices.
Claire BROSSAUD
doaj +1 more source
Verbum et Ecclesia, 2001 The life of modern people evolves around economics and all that goes with it, such as labour, production, consumption and possessions. These things do not only motivate many peoples' behaviour, but claim most of their energy and time. Therefore, the organising principle of life of people today is instrumental mastery - the individual's ability to ...
openaire +3 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The nature of process-produced data: towards a social-scientific source criticism
, 1980 Probleme des Alltagslebens werden zunehmend Gegenstand administrativer Datensammlung und Verarbeitung. Diese quantitativen Daten können von der Sozialwissenschaft nur dann sinnvoll in die Arbeit einbezogen werden, wenn ihre Entstehungsbedingungen und ihr Verwendungszusammenhang in der Verwaltung berücksichtigt werden.
Bick, Wolfgang, Müller, Paul J.
openaire +1 more source
Rational Reconstruction Reconsidered [PDF]
, 2010 Here is a dilemma concerning the history of science. Can the history of scientific thought be reduced to the history of the beliefs, motives and actions of scientists?
Nanay, Bence
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Fighting a Resurgent Hyper-Positivism in Education is Music to My Ears
, 2015 In this article, I argue that one of the gifts of the Age of Enlightenment, the ability to measure, to experiment, to predict—turned rancid by hyper-positivism—is re-asserting itself globally in the field of education (including music education). I see a
Williams, Hakim Mohandas Amani
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