Results 151 to 160 of about 178,707,044 (309)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
A Conceptual Framework for Action on the Social Determinants of Health
, 2010 Conceptual frameworks in a public health context shall in the best of worlds serve two equally important purposes: guide empirical work to enhance our understanding of determinants and mechanisms and guide policy-making to illuminate entry points for ...
core
Other title: Two Thousand Six Behavioral Risk Factor Surveillance System
, 2007 application/pdf; Report Preparation: Ghazala Perveen [and] Farooq Ghouri.; "Funding for data collection of Anxiety and Depression module using the 2006 Behavioral Risk Factor Survey was provided by cooperative agreement # U58/CCU722793-03 from the ...
Kansas. Office of Health Promotion.
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Abstract INTRODUCTION Social determinants of health (SDOH) may impact caregivers’ ability to implement evidence-based health practices at home during early childhood, especially in families with children with intellectual and developmental disabilities (IDD).
Tchoua, Phoebe P. +7 more
openaire +2 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Social Determinants of Health: Out-of-School-Time Programs
The Community Preventive Services Task Force (CPSTF) findings and recommendations for "Social Determinants of Health: Out-of-School-Time Academic Programs" are based on systematic reviews of evidence of effectiveness and economic impact.
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مجله اپیدمیولوژی ایران, 2017 Background and objective: Epidemiology is a tool and a field of Medical sciences which provides evidences necessary to make scientific decisions. This study aimed to identify strategies for the promotion of the epidemiology by Iranian Epidemiological ...
GH Moradi +9 more
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source