Results 41 to 50 of about 15,138 (291)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Aestimum, 2013 Following the crisis generated by the financialization of private real-estate, construction prices have gradually decreased depriving the housing market of the necessary growth stimuli.
Gianluigi De Mare +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Multiregional Models of Economic Interactions: Comparative Analysis
Пространственная экономикаThe article deals with the problems of measuring spatial multipliers on the basis of multiregional models of economic interactions. Two lines of comparative analysis of multiregional models are distinguished: 1) depending on the choice of trade ...
Natalya Gennadievna Dzhurka
doaj +1 more source
Journal of Transport and Supply Chain Management, 2012 This paper highlights the first attempt by researchers at Stellenbosch University to model freight flows between and for 17 countries in sub-Saharan Africa (SSA). The model will be informed by and linked to the South African surface Freight Demand Model (
Jan Havenga +5 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The Andalusian Tourism Sector during the Economic Crisis and its Impact on Regional Development
Revista de Estudios Andaluces, 2018 It is not common practice to assess tourism’s effects on regional development, although its benefits for host economies are widely known. This paper attempts to discern such activity’s role in a geographic setting by applying structural analysis ...
Ana Mª García-López +3 more
doaj +3 more sources
The Effects of the First Phase Implementation of Subsidy Targeting on the Welfare of Low Income Households Using Structural Path Analysis [PDF]
پژوهشهای اقتصادی, 2017 The implementation of any economic policy that has expansionary effects requires relatively stable economic conditions. Under such conditions it is expected that potential predictable effects of such policy implementation on welfare of households ...
soheila parvin, Ali Asghar Banouei
doaj
Spanish Journal of Agricultural Research, 2014 The concept of 'bioeconomy' is gathering momentum in European Union (EU) policy circles as a sustainable model of growth to reconcile continued wealth generation and employment with bio-based sustainable resource usage.
George Philippidis +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source