Results 41 to 50 of about 122,464 (289)
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Multiregional Models of Economic Interactions: Comparative Analysis
Prostranstvennaâ ÈkonomikaThe article deals with the problems of measuring spatial multipliers on the basis of multiregional models of economic interactions. Two lines of comparative analysis of multiregional models are distinguished: 1) depending on the choice of trade ...
Natalya Gennadievna Dzhurka
doaj +1 more source
Journal of Transport and Supply Chain Management, 2012 This paper highlights the first attempt by researchers at Stellenbosch University to model freight flows between and for 17 countries in sub-Saharan Africa (SSA). The model will be informed by and linked to the South African surface Freight Demand Model (
Jan Havenga +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
The Andalusian Tourism Sector during the Economic Crisis and its Impact on Regional Development
Revista de Estudios Andaluces, 2018 It is not common practice to assess tourism’s effects on regional development, although its benefits for host economies are widely known. This paper attempts to discern such activity’s role in a geographic setting by applying structural analysis ...
Ana Mª García-López +3 more
doaj +3 more sources
The Effects of the First Phase Implementation of Subsidy Targeting on the Welfare of Low Income Households Using Structural Path Analysis [PDF]
پژوهشهای اقتصادی, 2017 The implementation of any economic policy that has expansionary effects requires relatively stable economic conditions. Under such conditions it is expected that potential predictable effects of such policy implementation on welfare of households ...
soheila parvin, Ali Asghar Banouei
doaj
Spanish Journal of Agricultural Research, 2014 The concept of 'bioeconomy' is gathering momentum in European Union (EU) policy circles as a sustainable model of growth to reconcile continued wealth generation and employment with bio-based sustainable resource usage.
George Philippidis +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller +6 more
wiley +1 more source