Results 61 to 70 of about 13,987,623 (300)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
THE ROLE OF THE LEONTIEF'S ACCOUNTING METHOD AS A BRIDGE BETWEEN COMMODITY CENTERED AND HUMAN CENTERED APPROACHES [PDF]
فصلنامه پژوهشهای اقتصادی ایران, 2001 In this paper a brief review of Commodity Centred and Human Centred approaches is presented. The role of the existing accounting system and its related models in quantifying these approaches with respect to the following questions is analized: "To what ...
Ali Asghar Banouei
doaj
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The South African wildlife ranching sector: A Social Accounting Matrix Leontief multiplier analysis
Acta Commercii, 2014 Orientation: There is startlingly little economic research on the South African wildlife sector which contributes toward disputes regarding the economic contribution of the sector.
Philippus C. Cloete, Riaan Rosouw
doaj +1 more source
A 2017 Social Accounting Matrix for Myanmar [PDF]
, 2020 This paper documents the compilation of a 2017 Social Accounting Matrix for Myanmar. This is based on partial and unpublished National Accounts data and unpublished Supply and Use Table data, as well as Balance of Payment data and Government Finance Statistics data.
van Seventer, Dirk +4 more
openaire +2 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
A social accounting matrix for Scotland [PDF]
, 2014 Irrespective of the outcome of the September 2014 Scottish independence referendum, Scotland will require more and better economic data to manage its increased economic responsibilities. The 2012 Scotland Act and proposals by each major UK political party will further increase Scotland‟s fiscal powers.
Emonts-Holley, Tobias +2 more
openaire +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source