Results 241 to 250 of about 1,472,918 (305)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
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Social adjustment in rehabilitation
International Journal of Rehabilitation Research, 1984A three years' follow up study was carried out to assess the efficacy of a psychiatric rehabilitation service in an urban/suburban English district of about 200 000 population, by examining, a cohort of 100 rehabilitees who used the service. This paper briefly outlines the types of residential facilities available to the service and it describes the ...
M, Collis, M Y, Ekdawi
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Social Adjustment and Depression
Archives of General Psychiatry, 1973Social and interpersonal maladjustments found in depressed women were reassessed over an eight-month follow-up and compared with normal controls. Overall, there was considerable improvement in social adjustment, but it occurred more slowly than that for symptoms and left some residual deficits.
E S, Paykel, M M, Weissman
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International Social Adjustments
Social Forces, 1929T HE League of Nations is primarily and rightly considered as a political body. Its founders were concerned first of all with evolving some form of world organization which would do away with war. Consequently the greater part of the covenant and the major part of the League's activities-especially those which have received world wide attention-have ...
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Social Participation and Social Adjustment
The Journal of Educational Research, 1965(1965). Social Participation and Social Adjustment. The Journal of Educational Research: Vol. 58, No. 7, pp. 303-306.
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