Results 201 to 210 of about 13,017,750 (257)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
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Social Work in Health Care, 1984
AIDS (Acquired Immune Deficiency Syndrome) is a new contagious disease for which no cause or cure is known at present. The majority of people who have contracted AIDS is gay men. This paper examines individual and societal responses to this illness and to homosexuality that create issues for social work practice.
A L, Furstenberg, M M, Olson
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AIDS (Acquired Immune Deficiency Syndrome) is a new contagious disease for which no cause or cure is known at present. The majority of people who have contracted AIDS is gay men. This paper examines individual and societal responses to this illness and to homosexuality that create issues for social work practice.
A L, Furstenberg, M M, Olson
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Social Science & Medicine, 1987
AIDS as a new lethal and at present incurable sexually transmitted disease is already having remarkable social repercussions not yet fully explicit and hence it can be termed a social phenomenon. Political, behavioural, economic and legal reactions and social responses such as stigmatization, changes in the sick role and the growth of voluntary ...
openaire +4 more sources
AIDS as a new lethal and at present incurable sexually transmitted disease is already having remarkable social repercussions not yet fully explicit and hence it can be termed a social phenomenon. Political, behavioural, economic and legal reactions and social responses such as stigmatization, changes in the sick role and the growth of voluntary ...
openaire +4 more sources
Scientific American, 1988
Another aspect of AIDS epidemic is the public reaction or treatment of the disease and its victims and the potential for discriminatory actions. The issues of discrimination and treatment are compounded by the fact that AIDS is a disease transmitted sexually and that the disease has hit fringe groups such as homosexuals and intravenous drug users the ...
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Another aspect of AIDS epidemic is the public reaction or treatment of the disease and its victims and the potential for discriminatory actions. The issues of discrimination and treatment are compounded by the fact that AIDS is a disease transmitted sexually and that the disease has hit fringe groups such as homosexuals and intravenous drug users the ...
openaire +2 more sources
The Social Ecology of HIV/AIDS
Medical Clinics of North America, 2008The reasons that epidemics occur largely are a function of human behaviors and responses to environmental changes, known as the social ecology of infectious diseases. The AIDS epidemic began in remote parts of Central and West Africa and spread from rural areas to urban centers. The epidemic became a global pandemic. Although screening programs and use
Kenneth, Mayer +2 more
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