Results 51 to 60 of about 37,462 (252)

Psychometric properties of the Internalized Stigma of Mental Illness (ISMI-10) scale in a Dutch sample of employees with mental illness

BMC Psychiatry, 2022
Background: Internalized stigma can have numerous negative effects on the well-being and employment of people with mental illness. Brief, valid, and reliable measures are needed to get a better understanding of self-stigmatization.
I. E. van Beukering, M. Bakker, R. I. Bogaers, K. M.E. Janssens, S. Gürbüz, M. C.W. Joosen, E. P.M. Brouwers   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Data Health Assurance in Social and Behavioral Sciences Research [PDF]

, 2015
This illustrative study reincarnates the philosophical assumption of Methodology for science among other assumptions like Epistemology and Ontology in the context of social and behavioral sciences.
Anwar, Ch. Mahmood; US Press Association, Boone
core  

The Use of Subscores in Higher Education: When Is This Useful?

Frontiers in Psychology, 2017
Assessment in higher education is challenging because teachers face more students, with less contact time as compared to primary and secondary education.
Rob R. Meijer, Anja J. Boevé, Jorge N. Tendeiro, Roel J. Bosker, Casper J. Albers   +4 more
doaj   +1 more source

Infections in Biological and Targeted Synthetic Drug Use in Rheumatoid Arthritis: Where do We Stand? A Scoping Review and Meta-analysis

Rheumatology and Therapy, 2023
Introduction The advent of biological and targeted synthetic therapies has revolutionized rheumatoid arthritis (RA) treatment. However, this has come at the price of an increased risk of infections.
Barbara J. M. Bergmans, Biniyam Y. Gebeyehu, Eugène P. van Puijenbroek, Katrijn Van Deun, Bennett Kleinberg, Jean-Luc Murk, Esther de Vries   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

IX. European Conference on Social and Behavioral Sciences, Paris

, 2016
. International Association of Social Science Research-IASSR organized ninth of its conference series as “European Conference on Social and Behavioral Sciences” themed on February 3-6, 2016, at Paris.
ALPTEKİN, M.Yavuz; Karadeniz Technical University, Department of Sociology, Trabzon, Turkey. . +90 462 3774378
core   +1 more source

Longitudinal changes in adolescents' prosocial giving to those in need during and following the COVID-19 pandemic

Frontiers in Developmental Psychology
The COVID-19 pandemic represented a dire time of global crisis with pandemic-related social restrictions drastically impacting the daily lives of youth.
Ethell-Marjorie Dubois, Yara J. Toenders, Sophie W. Sweijen, Suzanne van de Groep, Kayla H. Green, Lysanne W. te Brinke, Jeroen van der Waal, Eveline A. Crone   +7 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source