Results 111 to 120 of about 3,121,490 (346)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
‘Urbanisation of Everybody’, Institutional Imperatives, and Social Transformation in Pakistan [PDF]
Cultural change and social transformation are essential elements of the process of development. They complement and sustain economic growth. Economic historians acknowledge that the rise of the West from poverty to wealth was as much the result of ...
Mohammad A. Qadeer
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Le monde ne sera plus jamais le même : réflexions sémiotiques sur l’expérience du changement soudain
Cygne Noir, 2018 D’un point de vue sémiotique, l’expérience du changement soudain peut impliquer ou bien un excès de signes ou bien une absence de signes, situations qui toutes deux entraînent l’incapacité de former une représentation cohérente et qui, donc, empêchent la
Richard J. Parmentier
doaj
Evolutionary Synthesis in the Social Sciences and Humanities
Cultural Science, 2010 Cultural change constitutes a Darwinian evolutionary process, comprising the three Darwinian principles of variation, selection and inheritance. Yet cultural evolution is not identical to genetic evolution: the sources of variation, the forms of ...
Mesoudi Alex
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Philosophy of History: A problem with some theories of Speculative philosophy of history and substantive philosophy of history [PDF]
Karl Marx, Emile Durkheim, Leslie White, Allen Johnson and Timothy Earle, and Stephen Sanderson all produced some of the more interesting theories of history, social change and cultural evolution but their theories have a common deficiency.
Forrester, Rochelle Marianne
core
Development of company law in India : the case of the Companies Act 1956 [PDF]
, 2006 The influence of culture and politics on the promulgation of accounting regulations in the Companies Act 1956 in India immediately post independence is analysed using an exploratory framework based on the work of McKinnon (1986) and Gray (1988).
Gray, S.J., Verma, S.
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Social Media, Changing Culture and Policymaking
Strategic Public Management Journal, 2017 Social media is the new deal and it has changed the way we do communicate with one another. Before people were restrained by space and time but now there are no physical boundaries; social media networks are virtually global; people using the same platform share ideas from all over the world instantaneously.
Kandara, Mehtap, Hamza Çelikyay, Hicran
openaire +3 more sources