Results 141 to 150 of about 3,121,490 (346)
The cultural psychology of obesity: diffusion of pathological norms from Western to East Asian societies [PDF]
, 2007 We examine the accelerating worldwide obesity epidemic using a mathematical model relating a cognitive hypothalamic-pituitary-adrenal axis tuned by embedding cultural context to a signal of chronic, structured, psychosocial threat.
Wallace, Deborah, Wallace, Rodrick
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Social SciencesThis article theorizes the role of local and indigenous culture in its intersection with development initiatives. It argues that Communication for Development and Social Change (CDSC), through a cultural studies framework, strengthens the potentiality of
Lauren Dyll, Keyan G. Tomaselli
doaj +1 more source
Mapping cultural change and engineering consent – through social networks and identifying key stakeholders [PDF]
Purpose To provide insight into how Public Relations can be used in an innovative manner, when looking to harmonise social, resource-based and financial equity - through strengthening stakeholder relations and capitalising on dynamic extended networks ...
Wilson, Jonathan A.J.
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Climate change scepticism is largely social and not scientific in nature [PDF]
, 2012 Adam Corner argues that social views and cultural beliefs predict climate change denial, and not people’s level of knowledge about climate science. The crux of the climate debate, therefore, lies in untangling the competing visions of how people see the ...
Corner, Adam
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
La percepción de los cambios en los años sesenta
Studia Historica: Historia Contemporánea, 2010 RESUMEN: En los años sesenta los cambios políticos en España fueron poco significativos porque los que pudiera suponer la Ley Orgánica del Estado, los coartó su propia aplicación.
Glicerio SÁNCHEZ RECIO
doaj
Defense or attack? Can soccer clubs help tackle social exclusion? [PDF]
, 2004 This paper examines soccer as a social and cultural phenomenon which is increasingly being adopted as an instrument for social change. The economic power of soccer in the UK, and in many other parts of the world, is apparent with the fame and wealth ...
Holden, Philip, Wilde, Nicholas
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source