Results 61 to 70 of about 281,640 (302)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bio-environmental Differences Between Active and Silent Foci of Tick-Borne Encephalitis in Yugoslavia

Acta Biologica Slovenica
This paper considers the differences in climate and landscape, lxodid tick species composition, and intensity of small and other mammals' tick infestation in relation to that part of the human population which comes in contact with the tick-borne ...
Danica Tovornik, Marko Matjašič
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Children’s screen time and psychosocial symptoms at 5 years of age – the role of parental factors

BMC Pediatrics
Background and objectives Electronic media (e-media) has become a universal part of young children’s daily lives. Previous studies have found an association between increased screen time and children’s psychosocial symptoms.
Janette Niiranen, Olli Kiviruusu, Riitta Vornanen, Anneli Kylliäinen, Outi Saarenpää-Heikkilä, E. Juulia Paavonen   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pertinent facts concerning social welfare in Kansas. [1937]

, 1937
At head of title: ... State Board of Social Welfare of Kansas, R.B. Church - State Director.; Reproduced from typewritten copy.; "11-16-37."[County board of social welfare] -- Qualifications of employees -- How the program is financed -- A program of ...
Kansas. State Department of Social Welfare. Division of Public Relations.
core  

Marginalised groups protest against social welfare and public health: conceptualising the challenge for social workers [PDF]

, 2020
As neoliberalisation and other global disruptions change the understanding of human rights and social justice for social workers, how are protests organised by marginalised groups against social welfare and public health regimes understood and ...
Charles Chear, Aaslund, Håvard, Chear, Charles, Håvard Aaslund   +3 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Report of social welfare in Kansas. Report of public welfare in Kansas

, 1937
"Prepared by the Division of Research and Statistics"State of Kansas, Report of Social Welfare in 1937 Report of Social Welfare in Kansas (No. 2, 1938) Report of Social Welfare in Kansas (No. 3, 1939) Report of Social Welfare in Kansas (No.
Kansas. State Board of Social Welfare
core   +1 more source

Family communication, death taboo, and advance directives: a cross-sectional study of institutionalized older adults in China

BMC Palliative Care
Background A conceptually guided framework examining how family communication relates to advance directive completion rates among older adults may offer useful insights for improving end-of-life decision-making in aging societies.
Yan Tian, Wen You, Can Xu, Yuehua Zhang
doaj   +1 more source