Results 141 to 150 of about 1,161,238 (398)

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

open access: yesAdvanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria   +5 more
wiley   +1 more source

A translational neuroscience approach to understanding the development of social anxiety disorder and its pathophysiology.

open access: yesAmerican Journal of Psychiatry, 2014
This review brings together recent research from molecular, neural circuit, animal model, and human studies to help understand the neurodevelopmental mechanisms underlying social anxiety disorder.
A. Fox, N. Kalin
semanticscholar   +1 more source

Attentional bias and physiological stress sensitivity in children and adolescents with an anxiety disorder [PDF]

open access: yes, 2007
Although periods of heightened anxiety are part of normal psychological development (Gullone et al., 2 001; Stevenson-Hinde, & Shouldice, 1995; Westenberg et al., 2 004), a significant proportion of all children and adolescents report anxiety levels ...
Kallen, V.L. (Victor)
core  

Separaxion anxiety in pediatric migraine without aura: A pilot study [PDF]

open access: yes, 2017
Background: Separation anxiety (SA) can be defined as the fear reaction and protest manifested by children when the main caregivers move away from him/her or in front of unfamiliar person. SA near eight months may be considered as an important and normal
Di Filippo T.   +6 more
core   +1 more source

Neuroendocrine models of social anxiety disorder

open access: yesDialogues in Clinical Neuroscience, 2015
Social anxiety disorder (SAD) is a highly prevalent and disabling disorder with key behavioral traits of social fearfulness, social avoidance, and submissiveness. Here we argue that hormonal systems play a key role in mediating social anxiety, and so may be important in SAD.
van Honk, Jack   +4 more
openaire   +6 more sources

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song   +15 more
wiley   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

open access: yesAdvanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen   +13 more
wiley   +1 more source

Antiepileptic Drugs in the Treatment of Anxiety Disorders [PDF]

open access: yesPsikiyatride Güncel Yaklaşımlar, 2009
In addition to epilepsy, antiepileptic drugs are used in neurologic conditions such as chronic pain and in the treatment of bipolar disorder in psychiatry. There are studies reporting its use in the treatment of anxiety disorders.
Levent Mete   +2 more
doaj  

Taijin kyofusho: a form of social anxiety disorder that responds to serotonin reuptake inhibitors? [PDF]

open access: bronze, 2001
Hisato Matsunaga   +4 more
openalex   +1 more source

Irritable Bowel Syndrome patients exhibit depressive and anxiety scores in the subsyndromal range [PDF]

open access: yes, 2008
Irritable bowel syndrome (IBS) patients frequently experience affective disorders and psychiatric outpatients frequently meet criteria for IBS. The exact nature of this co-morbidity is not clear. 34 patients with Rome-II diagnosed IBS were recruited from
Hendry, Julie   +6 more
core   +2 more sources

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