Results 121 to 130 of about 16,450,097 (315)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Child Abuse, Misdiagnosed by an Expertise Center: Part I-Medico-Social Aspects. [PDF]

Children (Basel), 2023
Vlaming M, Sauer PJJ, Janssen EPF, van Koppen PJ, Bruijninckx CMA, Akkerman-Zaalberg van Zelst MWM, Neumann HAM, van Gemert MJC.   +7 more
europepmc   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Ethical, legal and social aspects of human cerebral organoids and their governance in Germany, the United Kingdom and the United States. [PDF]

Front Cell Dev Biol, 2023
Pichl A, Ranisch R, Altinok OA, Antonakaki M, Barnhart AJ, Bassil K, Boyd JL, Chinaia AA, Diner S, Gaillard M, Greely HT, Jowitt J, Kreitmair K, Lawrence D, Lee TN, McKeown A, Sachdev V, Schicktanz S, Sugarman J, Trettenbach K, Wiese L, Wolff H, Árnason G.   +22 more
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Risk Aspects of Investment-Based Social Security Reform [PDF]

James M. Poterba, Jeffrey R. Brown, Olivia S. Mitchell   +2 more
core   +15 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Analysis of the MSW management system in Bissau, Guinea-Bissau, in the light of sustainable development goals (SDG)

RUDN Journal of Ecology and Life Safety
The study analyzes the existing system of solid municipal waste management in the capital of the Republic of Guinea-Bissau - Bissau. Based on the analysis, facts of ineffective waste management, lack of operational control and systematization of data in ...
Fernando Nantungue, Marianna D. Kharlamova   +1 more
doaj   +1 more source

Social aspects of collision avoidance: a detailed analysis of two-person groups and individual pedestrians. [PDF]

Sci Rep, 2023
Gregorj A, Yücel Z, Zanlungo F, Feliciani C, Kanda T.   +4 more
europepmc   +1 more source