Results 191 to 200 of about 12,690,531 (300)

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

The Effect of Old Age Assistance on Retirement [PDF]

open access: yes
Researchers have devoted considerable attention to analyzing the impact of Social Security on retirement, with mixed findings. However, Old Age Assistance (OAA), a means-tested program established at the same time, dwarfed Social Security until the 1950s
Leora Friedberg
core  

Social Assistance Monitoring in Social Assistance Policy: Conception and Operation

open access: yes, 2015
Este texto propõe um debate sobre a Vigilância Socioassistencial, que faz parte dos objetivos da política no Sistema Único de Assistência Social (SUAS). Aborda, especificamente, a base organizacional da gestão no SUAS e o processo da implantação da Vigilância Socioassistencial em Porto Alegre/RS, a partir de 2013.
Martinelli, Tiago   +2 more
openaire   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Social Assistance Benefit Rates and the Employment Rate of Lone Mothers [PDF]

open access: yes
The results show that the increase in social assistance benefits has been a major factor behind the decline in employment rates of lone mothers in Ontario.
Kapsalis, Constantine
core  

Understanding the Reasons Why Patients With Food Insecurity Decline Social Assistance at a Large Academic Medical Center. [PDF]

open access: yesAJPM Focus
Connelley A   +9 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

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