Results 91 to 100 of about 12,604,585 (206)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Kansas State Technical Assistance Program.
, 1965 Includes two Executive Orders and an Executive Appointment by Governor William H.
Kansas. State Technical Assistance Program. Office of the Coordinator.
core
Цифровая социологияThe article is devoted to a sociological analysis of the opinions of family mediation specialists on the problems of spousal negotiability and domestic violence.
O. E. Gracheva, I. V. Mkrtumova
doaj +1 more source
EVALUATION MODELS APPLIED TO PUBLIC POLICIES IN ROMANIA ON THE INTEGRATION OF YOUNG PEOPLE INTO THE LABOR MARKET [PDF]
Challenges of the Knowledge Society, 2018 Due to the changes imposed by the national public institutions in the field of labor market, the public policies in the field need to be correlated with the new socio-economic context.
Ștefania Cristina STANCIU
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Social Jealousy and Stigma: Negative Externalities of Social Assistance Payments in Germany [PDF]
This paper examines the role of social assistance payments (SAP or Sozialhilfe) in determining levels of life satisfaction in Germany using the SOEP 1995–2004. We find strong evidence that individuals in Germany are negatively influenced by increased SAP
Sonja C. Kassenboehmer +1 more
core
Three Paradigms of Social Assistance
SAGE Open, 2014 “Ideas,” which are defined as the normative and cognitive beliefs of actors, are fundamental to a full understanding of the welfare state and, in particular, of social assistance.
Pierre-Marc Daigneault
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
SOCIAL ASSISTANCE IN ROMANIA IN THE CONTEXT OF EUROPEAN INTEGRATION AND GLOBALIZATION [PDF]
Buletin ştiinţific: Universitatea din Piteşti. Seria Ştiinţe Economice, 2015 Given the changes that have occurred within the demographic structure of the population and the framework of the labour market, there is a both a global and national concern towards the continuous reconceptualization of the field of assistance.
Gheorghe MATEI, Nicolae TUDOSE
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source