Results 61 to 70 of about 468,155 (259)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

FEATURES OF FIRST-GRADERS’ ADAPTATION TAKING INTO ACCOUNT THE INDIVIDUAL TYPOLOGICAL INDICATORS AND SIGNS OF DEVELOPMENT DEFICIENCIES

Вестник Кемеровского государственного университета, 2015
An experimental investigation of physiological parameters of the central nervous system and the adaptation of firstgraders with different development deficiencies was performed.
N. P. Krivosheina, A. I. Fedorov, E. M. Kazin, I. A. Sviridova, N. N. Koshko, M. S. Kolomeets   +5 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

DIMINUAREA STRESULUI LA TINERI

Psihologie
Articolul descrie conținutul programului de intervenții psihologice orientat spre diminuarea nivelului de stres. Experimentul formativ a inclus un număr de 24 tineri cu nivel ridicat și moderat al stresului: 12 tineri în grupul experimental (GE) și 12 în
Irina VLAS
doaj   +1 more source

Role-Playing (Psychodrama) in the Social Rehabilitation of Juveniles [PDF]

Polish Journal of Social Rehabilitation, 2015
The article discusses the term of psychodrama in the aspect of the social rehabilitation process of juveniles. An important area of considerations is noting the most effective form of work in the modification of socially desirable behavior. Moreover, the
Barbara Grzyb, s. Bogumiła Gardziejewska   +1 more
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

ASPECTS OF THE CIVIL SERVANT'S CAREER AND MANAGEMENT IN ROMANIA IN THE SARS-COV2 PERIOD [PDF]

Challenges of the Knowledge Society
The institution of the civil servant emerged on its own in the 20th century and its importance is growing in all democratic countries. And in Romania, even if it is subordinated to the political factor, the civil servant institution should be ...
Narcis Dumitru BADEA
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

QUALITY ASSESSMENT OF HIGHER EDUCATION INSTITUTIONS WITH ARTISTIC PROFILE IN ROMANIA [PDF]

Revista Română de Sociologie, 2013
At the meeting of European ministers responsible with higher education, which took place in Berlin in September 2003, a series of important measures were initiated; research activity and the quality assessment were declared as major priorities.
ADRIANA ŞERBAN
doaj