Results 121 to 130 of about 463,843 (262)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Describing the linkage between administrative social assistance and health care databases in Ontario, Canada. [PDF]

Int J Popul Data Sci, 2022
de Oliveira C, Gatov E, Rosella L, Chen S, Strauss R, Azimaee M, Paterno E, Guttmann A, Ministry of Children, Community and Social Services-ICES Working Group (Nelson Chong, Peter Lonescu, Sean Ji, Alexander Kopp, Annie Lan, Charlotte Ma, Miranda Pring, Priyanka Raj, Steven Ryan, Refik Saskin, Fiona Wong).   +19 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Research priorities to reduce risks from work hours and fatigue in the healthcare and social assistance sector. [PDF]

Am J Ind Med, 2022
Caruso CC, Arbour MW, Berger AM, Hittle BM, Tucker S, Patrician PA, Trinkoff AM, Rogers AE, Barger LK, Edmonson JC, Landrigan CP, Redeker NS, Chasens ER.   +12 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Introducing CARESSER: A framework for in situ learning robot social assistance from expert knowledge and demonstrations. [PDF]

User Model User-adapt Interact, 2023
Andriella A, Torras C, Abdelnour C, Alenyà G.   +3 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Implementation and evaluation of a peer-to-peer support program in oncology: study protocol for the PaRole Onco France model

Archives of Public Health
Background Peer support interventions in oncology have shown potential benefits for patients, including reduced psychological distress, improved empowerment, and enhanced care experience.
Yaël Busnel, Marie-Pascale Pomey, Anne Termoz, Véronique Christophe, Christophe Tournigand, Emmanuelle Jouet, Laurie Panse, Stéphane Cognon, Claude Ganter, Alexandra Villate, Pauline Maisani, Marie Preau, Julie Haesebaert, Proof investigators group   +13 more
doaj   +1 more source

Social Assistance Programs and Birth Outcomes: A Systematic Review and Assessment of Nutrition and Health Pathways. [PDF]

J Nutr, 2021
Leroy JL, Koch B, Roy S, Gilligan D, Ruel M.   +4 more
europepmc   +1 more source