Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The article is devoted to a sociological analysis of the opinions of family mediation specialists on the problems of spousal negotiability and domestic violence.
O. E. Gracheva, I. V. Mkrtumova
doaj +1 more source
EVALUATION MODELS APPLIED TO PUBLIC POLICIES IN ROMANIA ON THE INTEGRATION OF YOUNG PEOPLE INTO THE LABOR MARKET [PDF]
Due to the changes imposed by the national public institutions in the field of labor market, the public policies in the field need to be correlated with the new socio-economic context.
Ștefania Cristina STANCIU
doaj
Three Paradigms of Social Assistance
“Ideas,” which are defined as the normative and cognitive beliefs of actors, are fundamental to a full understanding of the welfare state and, in particular, of social assistance.
Pierre-Marc Daigneault
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Social assistance and poverty reduction in Moldova, 2001-2004 an impact evaluation [PDF]
This paper assesses the impact of social assistance benefits on household welfare in Moldova. Ignoring standard issues of impact evaluations such as selection bias, behavioral responses, unobserved heterogeneity and endogeneity, an incidence analysis ...
Verme, Paolo
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
SOCIAL ASSISTANCE IN ROMANIA IN THE CONTEXT OF EUROPEAN INTEGRATION AND GLOBALIZATION [PDF]
Given the changes that have occurred within the demographic structure of the population and the framework of the labour market, there is a both a global and national concern towards the continuous reconceptualization of the field of assistance.
Gheorghe MATEI, Nicolae TUDOSE
doaj
Geographic microtargeting of social assistance with high-resolution poverty maps. [PDF]
Smythe IS, Blumenstock JE.
europepmc +1 more source
2016/2017 Allocation plan for the Low Income Home Energy Assistance Program block grant.
Annua
Connecticut Energy Assistance Program.
core

