Results 51 to 60 of about 553,674 (309)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Leadership Styles During Crisis: ‘We’re All In This Together... The Crisis As New Normality’
Transylvanian Review of Administrative Sciences, 2016 The study comprises an inquiry into decision- making managerial styles and attitudes towards crisis and recession, by means of 219 structured interviews conducted with managers in 2009, 2015 and 2016.
Marian PREDA, Oana Maria STAN
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Вестник Кемеровского государственного университета, 2015 An experimental investigation of physiological parameters of the central nervous system and the adaptation of firstgraders with different development deficiencies was performed.
N. P. Krivosheina +5 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Role-Playing (Psychodrama) in the Social Rehabilitation of Juveniles [PDF]
Polish Journal of Social Rehabilitation, 2015 The article discusses the term of psychodrama in the aspect of the social rehabilitation process of juveniles. An important area of considerations is noting the most effective form of work in the modification of socially desirable behavior. Moreover, the
Barbara Grzyb +1 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Social Assistance in Sweden 1990-1995 [PDF]
Despite being a very hot subject in the public debate, the causes behind the increase in social assistance (SA) in the 1990s are relatively unknown. In this paper, I try to investigate if the increase is in part a result of an increase in the propensity ...
Arslanogullari, Sebastian
core
ASPECTS OF THE CIVIL SERVANT'S CAREER AND MANAGEMENT IN ROMANIA IN THE SARS-COV2 PERIOD [PDF]
Challenges of the Knowledge SocietyThe institution of the civil servant emerged on its own in the 20th century and its importance is growing in all democratic countries. And in Romania, even if it is subordinated to the political factor, the civil servant institution should be ...
Narcis Dumitru BADEA
doaj