Results 81 to 90 of about 2,584,706 (304)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Employment and Wages in Community and Social Service Occupations [PDF]
, 2012 People who work in community and social service occupations are concerned with improving society and the lives of individuals. These workers perform a diverse array of duties that may include counseling individuals with substance abuse and behavioral ...
Jones, John I
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Implicaţii morale ale cercetării şi practicii sociologice. O pledoarie pentru etică
Sociologie Românească, 2014 The paper was conceived as a pleading for the consideration of ethical issues and concerns posed by sociological professions. Starting from emphasizing the role and place of ethics in defining professions, the paper develops arguments in favor of ...
Ionel Cioară
doaj
SocietiesThis study aimed to evaluate Romanian university students’ perceptions of career counseling and guidance (CCG) services provided in 2022–2023. A quantitative methodology was employed, analyzing survey data (n = 7402 respondents from 18 universities) to ...
Claudiu Coman +3 more
doaj +1 more source
Devolution as a means to adequate social safety nets? [PDF]
Decentralisation is invariably among the recommendations that international organisations such as the World Bank make for an enhancement of social provisions, and particularly a better targeting of social assistance regimes, in Eastern and Central Europe.
De Maesschalck, Veerle +1 more
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Effects of social assistance on self-rated health. [PDF]
Front Public Health, 2022 Shao S, Che T, Zhou D.
europepmc +1 more source