Results 231 to 240 of about 4,628,488 (329)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Sex-specific cortical networks drive social behavior differences in an autism spectrum disorder model. [PDF]

Transl Psychiatry
Pais ML, Sereno J, Tomé VA, Fonseca C, Seco C, Ribeiro I, Martins J, Fortuna A, Abrunhosa A, Pinto L, Castelo-Branco M, Gonçalves J.   +11 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

High-Level Exposure of Testosterone During Mouse Pregnancy Impairs the Offspring Social Behavior by Interrupting Neurexin-Neuroligin Binding. [PDF]

Neurol Int
Yagishita-Kyo N, Yagishita S.
europepmc   +1 more source

The Effect of Corporate Social Responsibility on Brand Image and Behavioral Intention in Franchised Coffeehouse- A Focus on Moderating Effect of Communication Channel

, 2014
김유진, Kiyong Park, 김원태
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice

Wei Zhou, Samuel Daniels, Vijay Paul Singh, Marissa Menard, Martha L. Escobar Galvis, Hong‐Yuan Chu   +5 more
openalex   +1 more source

On connection of the social choice problem with an opportunity of authors’ speech behavior evaluation

, 2019
I V Dombrovskaya, И. П. Половинкин   +1 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source