Results 131 to 140 of about 476,960 (310)

Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology

, 2014
This revision of the 2005 British Association for Psychopharmacology guidelines for the evidence-based pharmacological treatment of anxiety disorders provides an update on key steps in diagnosis and clinical management, including recognition, acute ...
den Boer, J.A., Fineberg, N.A., Bandelow, B., Davies, S., Nutt, David J, Wee, N. van der, Fineberg, Naomi, Scott, Jan, O'Neill, C., Anderson, I.M., Nutt, D.J., O’Neill, C., Scott, J., Allgulander, Christer, Christmas, D.M., Christmas, David M, Fineberg, N., Davies, Simon, Allgulander, C., Anderson, Ian M., McCrone, P., Wittchen, H-U, Christmas, David M., van der Wee, N., Anderson, Ian M, Malizia, A., Nutt, David J., O'Neill, Catherine, Baldwin, D.S., Lidbetter, N., Lidbetter, Nicky, Bandelow, Borwin, Nabarro, Daniel, Malizia, Andrea, McCrone, Paul, van der Wee, Nic, Wittchen, Hans-Ulrich, Baldwin, David S., Baldwin, David S, den Boer, Johan A, Nabarro, D., Boer, J.A. den, Wittchen, H.U., Fineberg, Naomi A., den Boer, Johan A.   +44 more
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Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Associations between social anxiety disorders and the social aspects of young people's internet and mobile phone use [PDF]

, 2006
This thesis investigates young people's use of the Internet and mobile phones, and focuses especially on associations between use of these technologies for communication purposes and social anxiety. First, two surveys are reported which examine the broad
Madell, Dominie Edward
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Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Peri-adolescence isolation rearing alters social behavior and nociception in rats

, 2010
Social isolation results in fundamental behavioral abnormalities in rodents which models certain neuropsychiatric disorders such as schizophrenia. However, the developmental stage that is most vulnerable to social isolation is largely unknown.
Meng, Qingxuan, Wang, Weiwen, Shao, Feng, 王玮文, Han, Xiao, Feng Shao, Li, Nanxin   +6 more
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Sex differences in interpretation bias in adolescents

, 2016
Interpretation biases, in which ambiguous information is interpreted negatively, have been hypothesized to place adolescent females at greater risk of developing anxiety and mood disorders than same-aged males.
Lynn, Debra Alana, Dritschel, Barbara, Brown, Gillian Ruth, Gluck, Rachel   +3 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The role of positive and negative childhood events in the risk of developing personality disorders

, 2015
Existing research has predominantly focused on a limited range of childhood events and personality disorders, such as childhood maltreatment and borderline personality disorder.
Chua, M
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