Results 111 to 120 of about 14,030,900 (253)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Social marketing as a behaviour change strategy to increase tourists' pro-environmental behaviour

, 2023
This chapter explores the value that social marketing can bring to subject areas such as sustainable tourism. Social marketing seeks to develop and integrate marketing concepts with other approaches to influence behaviour that benefits individuals and ...
Lawson, A., Tomasella, B., Akbar, B., Azara, I.   +3 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism

Open Biology
Oxytocin (OXT) neurons in the paraventricular nucleus of the hypothalamus (PVN), which send projections to the medial amygdala (MeA) and the bed nucleus of the stria terminalis (BnST), are implicated in regulation of prosocial-emotional behaviours and ...
Yuki Higuchi, Akihiko Ozawa, Ryuki Kobayashi, Toshihiro Konno, Hiroyuki Arakawa   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Toys for children and adolescents: gendered preferences and developmental utilities

International Journal of Adolescence and Youth
A toy is an object or device designed for play and enjoyment. Engagement of children and adolescents with appropriate toys can have significant influences on their cognitive, emotional and socio-psychological development. In this review, we first discuss
Athira Smita Nair, Lakshmi Pillai, Pratik Bhattacharya, Darin Mansor Mathkor, Shafiul Haque, Faraz Ahmad   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Despotism promotes dyadic cooperation through enhanced interdependencies in non-human primate societies

Nature Communications
Cooperation is the cornerstone of human societies, and its emergence is firmly linked to enhanced tolerance and egalitarianism. However, evidence of profuse cooperation in less tolerant and despotic societies challenges this predominant view.
Debottam Bhattacharjee, Tonko W. Zijlstra, Tom S. Roth, Elena Belli, Sophie Calis, Paula Escriche Chova, Eythan Cousin, Jolanda A. de Jong, Edwin J. A. M. de Laat, Aníta Rut Guðjónsdóttir, Karline R. L. Janmaat, Elja J. Jeunink, Charlotte E. Kluiver, Penny E. N. Kuijer, Esmee Middelburg, Lena S. Pflüger, Veera I. Schroderus, Eva S. J. van Dijk, Jonas Verspeek, Sophie Waasdorp, Adam N. Zeeman, Elisabeth H. M. Sterck, Edwin J. C. van Leeuwen, Jorg J. M. Massen   +23 more
doaj   +1 more source