Results 221 to 230 of about 14,030,900 (253)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Mice Recognise Mice in Neighbouring Rearing Cages and Change Their Social Behaviour. [PDF]

Behav Neurol
Ueno H, Takahashi Y, Mori S, Murakami S, Wani K, Matsumoto Y, Okamoto M, Ishihara T.   +7 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Investigating the Interplay between Olfaction, Social Behaviour, and Individual Differences: Editorial. [PDF]

Brain Sci
Zou L, Mahmut MK.
europepmc   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

de Hoyos L, Schlag F, Jahagirdar S, Corfield EC, Allegrini AG, Admiraal DAG, de Zeeuw EL, Nolte IM, Llonga N, Neumann A, Lange K, van den Bedem S, Du Rietz E, Motazedi E, Eising E, Ng NYT, Palviainen T, Wang CA, Thiering E, Scatolin S, Choudhary P, Vilor-Tejedor N, Liao Z, Alemany S, Pedersen CT, Fernandez-Jimenez N, Campbell ML, Girchenko P, Barthome E, Seelemeyer H, Kumar A, Jeanne A, Ahluwalia TS, Black MH, Buitelaar JK, Fisher SE, Heiskala A, Hernández-Lorca M, Jaddoe VW, Järvelin M, Koopowitz S, Lake MT, Lichtenstein P, Llop S, Luo M, Malmberg A, Marí S, Oldehinkel AJ, Pausova Z, Pennell CE, Plomin R, Reichborn-Kjennerud T, Reilly S, Rodriguez A, Rolland T, Ronald A, Räikkönen K, Shin J, Artigas MS, Tate AE, Tiemeier H, Verhoef E, Vuoksimaa E, Wake M, Warrier V, Ystrom E, Bölte S, Ecker C, Bourgeron T, Lahti J, Stein DJ, Bilbao JR, Bønnelykke K, Bustamante M, Paus T, Middeldorp CM, Sunyer J, Sebert S, Standl M, Whitehouse AJO, Kaprio J, Ramos-Quiroga JA, Ribases M, Casas M, Bosch R, Morgan AT, Vrijkotte TGM, Larsson H, Cecil CAM, Hartman CA, Boomsma DI, Rimfeld K, Havdahl A, St Pourcain B.   +93 more
europepmc   +1 more source