Results 81 to 90 of about 568,075 (301)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Implementing the social pedagogic approach for workforce training and education in England: a preliminary study [PDF]
, 2007 Implementing the Social Pedagogic Approach for Workforce Training and Education in England is a study that was developed in conjunction with DfES and the Social Exclusion Task Force.
Cameron, Claire +2 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
BMC Public Health, 2017 Background This systematic review aimed to identify facilitators, barriers and strategies for engaging ‘hard to reach’ older people in research on health promotion; the oldest old (≥80 years), older people from black and minority ethnic groups (BME) and ...
Ann E. M. Liljas +6 more
doaj +1 more source
"Public Job-creation Programs: The Economic Benefits of Investing in Social Care. Case Studies in South Africa and the United States" [PDF]
This paper demonstrates the strong impacts that public job creation in social care provisioning has on employment creation. Furthermore, it shows that mobilizing underutilized domestic labor resources and targeting them to bridge gaps in community-based ...
Kijong Kim, Rania Antonopoulos
core
Care in mind : improving the mental health of children and young people in state care in Scotland [PDF]
, 2004 Some five thousand children and young people are in residential and foster care in Scotland. Many experience poor outcomes and concern about the quality of care has led to a number of government initiatives including the registration of care services and
Furnivall, Judy +2 more
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Moving Care to the Community: An International Perspective [PDF]
, 2013 Medical treatments that were once provided in hospital are being increasingly administered in the community. Within health systems, there is a renewed focus on delivering general health care in the community, freeing hospitals to provide more complex ...
core
Developing the mental health workforce capacity in primary care: implementing the role of graduate primary care mental health workers in England [PDF]
, 2007 The scale of current demand on primary care services from people seeking help with common mental health problems places enormous pressure on the existing front line workers in general practice.
Chadwick, Siobhan +3 more
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source