Results 121 to 130 of about 452,232 (264)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Internalized weight stigma and obesity-related quality of life in adults with obesity or overweight: a cross-sectional study across clinical and community settings. [PDF]

Eat Weight Disord
Manzoni GM, Tomba E, Gardini V, Cena H, Schumann R, Ballardini D, Donini LM, Manzato E, Gravina G, Di Pauli D, Castelnuovo G, Mazzoni C.   +11 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Social determinants of health and sex differences: insights from NIH Specialized Centers of Research Excellence (SCORE). [PDF]

Biol Sex Differ
A McKee S, Chang L, M Aris I.
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Frailty among older adults in Germany: regional variation across NAKO study centers. [PDF]

Int J Equity Health
König M, Rach S, Mikolajczyk R, Schöttker B, Mons U, Amthor M, Völzke H, Meinke-Franze C, Harth V, Obi N, Schulze MB, Thorand B, Greiser KH, Leitzmann M, Herrmann A, Lieb W, Kiekert J, Keil T, Krist L, Schmidt B, Heise JK, Nimptsch K, Pischon T, Ittermann T.   +23 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Social Center at Esslingen - Germany

Informes de la Construccion, 1969
Al mismo tiempo de constituir un Centro de vida social de la ciudad, este edificio recreativo destinado a múltiples usos sirve para la celebración: de bailes, conferencias, reuniones políticas, tertulias, etc. Dispone de un amplio salón de baile, y de uno de los más importantes restaurantes de Esslingen.
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Social Progress Index as a Determinant of Healthcare Access and Treatment in Pancreatic Cancer. [PDF]

Curr Oncol
Tustumi F, Maegawa FAB, Caraciolo VB, Shimoda GM, Rufino IPL, Dos Santos BAG, Stolzemburg LCP, Szor DJ, Araujo SEA, Uson Junior PLS, Wolosker N.   +10 more
europepmc   +1 more source