Results 261 to 270 of about 1,880,904 (318)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

EXPRESSION OF CONCERN: A Newly Identified 45‐kDa JAK2 Variant with an Altered Kinase Domain Structure Represents a Novel Mode of JAK2 Kinase Inhibitor Resistance

Molecular Oncology, EarlyView.
wiley   +1 more source

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Social Statistics and Social Change

Journal of the Australian Population Association, 1987
Although it is customary to regard the statistical product of modern nation-states as being composed of two broad categories, social statistics and economic statistics, this paper emphasizes the links rather than the dividing lines between statistical programmes. It traces the attempts of three statistician economists to classify and quantify “national
openaire   +2 more sources

ADOLESCENCE AND SOCIAL CHANGE

Journal of the American Academy of Child Psychiatry, 1970
The primary preoccupation of the psychoanalyst as a therapist has been with the psychopathology of intrapsychic functioning. At the same time he has always been a student of normal development and behavior, and of environment and culture. A knowledge of the range of normality is of course necessary for adequate di agnostic assessment, and a knowledge ...
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Social Service or Social Change?

2017
I first began thinking about this issue when the Oakland Men’s Project was established in 1979. At that time, we were responding to women in the domestic violence, sexual assault prevention, and child sexual assault prevention movements. When asked what we could do as men they said that they had their hands full dealing with the survivors of male ...
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LONELINESS AND SOCIAL CHANGE

American Journal of Psychiatry, 1955
Rapprochement between psychiatry and sociology has developed rapidly during the last few years. In theory and in research there is more collaboration than ever before and every prospect that this interdisciplinary trend will continue for some time to come. The present discussion is a case in point. It lies in the emerging field of social psychiatry (or
openaire   +2 more sources