Results 41 to 50 of about 6,972,461 (360)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Bonding, Bridging, and Social Change [PDF]

open access: yes, 2009
This paper discusses the efficacy of using Robert Putnam’s theory of social capital as the framework for forming long-term reciprocal relationship amongst Writing students, faculty, clients and staff of a community-based agency.
Nester, Nancy L.
core   +1 more source

The Optimal Distribution of Surgery in Low- and Middle-Income Countries: A Proposed Matrix for Determining Country-Level Organization of Surgical Services – A Response to the Recent Commentaries [PDF]

open access: yesInternational Journal of Health Policy and Management, 2022
Katherine R. Iverson   +8 more
doaj   +1 more source

Multi-level strategy to promote equity through empowerment and participation

open access: yesInternational Journal of Integrated Care, 2019
Introduction: Health inequities are recognised as one of the core challenges faced affecting population health worldwide. The Sustainable Development Goals (SDGs) and their focus on leaving no one behind have put equity at the centre of efforts to pursue
Anna Giné March   +3 more
doaj   +1 more source

Generational differences in climate-related beliefs, risk perceptions and emotions in the UK

open access: yesCommunications Earth & Environment, 2023
It is widely believed that younger generations are more engaged with climate change than older generations. However, evidence of a gap in climate-related perceptions and concern is mixed, likely due to the inconsistent use of outcome variables.
Wouter Poortinga   +2 more
doaj   +1 more source

Zero carbon transitions: a systematic review of the research landscape and climate mitigation potential

open access: yesFrontiers in Energy Research, 2023
Academia has a crucial role to play in informing urgently needed actions on climate mitigation. It is vital to understand what is known about the potential contribution of climate mitigation options, the barriers that exist to achieving that contribution,
Alexander Shaw   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Nature, society and social change [PDF]

open access: yes, 2012
Environmental destruction has become an everyday reality in the contemporary world. Major concerns are being put forward regarding the dangers to the environment in general and to human societies in particular, with strong focus currently being put on ...
Briguglio, Michael
core   +1 more source

Conflict between background matching and social signalling in a colour-changing freshwater fish [PDF]

open access: yes, 2016
The ability to change coloration allows animals to modify their patterning to suit a specific function. Many freshwater fishes, for example, can appear cryptic by altering the dispersion of melanin pigment in the skin to match the visual background ...
Kelley, Jennifer L.   +2 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

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