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Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Bonding, Bridging, and Social Change [PDF]
This paper discusses the efficacy of using Robert Putnam’s theory of social capital as the framework for forming long-term reciprocal relationship amongst Writing students, faculty, clients and staff of a community-based agency.
Nester, Nancy L.
core +1 more source
The Optimal Distribution of Surgery in Low- and Middle-Income Countries: A Proposed Matrix for Determining Country-Level Organization of Surgical Services – A Response to the Recent Commentaries [PDF]
Katherine R. Iverson +8 more
doaj +1 more source
Multi-level strategy to promote equity through empowerment and participation
Introduction: Health inequities are recognised as one of the core challenges faced affecting population health worldwide. The Sustainable Development Goals (SDGs) and their focus on leaving no one behind have put equity at the centre of efforts to pursue
Anna Giné March +3 more
doaj +1 more source
Generational differences in climate-related beliefs, risk perceptions and emotions in the UK
It is widely believed that younger generations are more engaged with climate change than older generations. However, evidence of a gap in climate-related perceptions and concern is mixed, likely due to the inconsistent use of outcome variables.
Wouter Poortinga +2 more
doaj +1 more source
Academia has a crucial role to play in informing urgently needed actions on climate mitigation. It is vital to understand what is known about the potential contribution of climate mitigation options, the barriers that exist to achieving that contribution,
Alexander Shaw +3 more
doaj +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Nature, society and social change [PDF]
Environmental destruction has become an everyday reality in the contemporary world. Major concerns are being put forward regarding the dangers to the environment in general and to human societies in particular, with strong focus currently being put on ...
Briguglio, Michael
core +1 more source
Conflict between background matching and social signalling in a colour-changing freshwater fish [PDF]
The ability to change coloration allows animals to modify their patterning to suit a specific function. Many freshwater fishes, for example, can appear cryptic by altering the dispersion of melanin pigment in the skin to match the visual background ...
Kelley, Jennifer L. +2 more
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source

