Results 241 to 250 of about 517,196 (309)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Using Discrete Choice Experiments (DCEs) to Compare Social and Personal Preferences for Health and Well-Being Outcomes. [PDF]

Med Decis Making
Wickramasekera N, Ta AT, Field B, Tsuchiya A.   +3 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Validity and Applicability of the Eating Motivation Survey (TEMS) in a University Population in the Western Brazilian Amazon. [PDF]

Int J Environ Res Public Health
Dias FSB, Silva WRD, Silva-Nunes MD, Ramalho AA.   +3 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A social prescribing model for tackling the health and social inequalities of people living with severe mental illness: a protocol paper. [PDF]

BMC Public Health
Leavey G, Watterson R, McAnee G, Shannon S, Boyd K, Lloyd-Evans B, Killaspy H, Miller I, Whitaker P, Golden S, Boyd G, Ross L, Curran R, Wylie S, Breslin G, Davidson G.   +15 more
europepmc   +1 more source

Deciding When to Align: Computational and Neural Mechanisms of Goal-Directed Social Alignment. [PDF]

Brain Sci
Sobeh A, Shamay-Tsoory S.
europepmc   +1 more source

Protocol for the quantitative assessment of social and nonsocial reward-seeking in mice using an automated two choice operant assay

Jennifer Isaac, Hymavathy Balasubramanian, Sonia Karkare, Nicholas Schappaugh, Malavika Murugan   +4 more
openalex   +1 more source

Factors contributing to food choice in the UK secondary school food setting: a systems map perspective. [PDF]

Public Health Nutr
O'Kane N, Hunter R, Schliemann D, Garcia L, Woodside J, Generating Excellent Nutrition in UK Schools (GENIUS) Network.   +5 more
europepmc   +1 more source

Behavioural economics intervention to implement a nutrition ranking system in food pantries: Be Well cluster randomised controlled trial protocol. [PDF]

BMJ Public Health
Perez PD, Faulkner KC, Wu Y, Schwartz MB, Caspi C, Burgun R, Ortiz L, Jia J, Cheng J, Chang Y, Levy DE, Thorndike AN.   +11 more
europepmc   +1 more source