Results 151 to 160 of about 2,854,644 (345)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Rational Choice, Scientific Method and Social Scientism [PDF]

open access: yes
The eighteenth-century introduction of the scientific method of the natural sciences to the study of social phenomena draws a line between moral philosophy Ethat aspect of ancient and medieval philosophy that dealt with social issues Eand the social ...
Bongo Adi   +2 more
core  

Psycho-Socio-Cultural Determinants of Food Choice: A Qualitative Study on Adults in Social and Cultural Context of Iran

open access: yesIranian Journal of Psychiatry, 2017
Background: Food choice is a process through which people think, feel, and eat food. It is not only influence individuals' health and well-being, families and communities, but also has effect on regional, national, and global levels.
Arezoo Haghighian Roudsari   +6 more
doaj  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

open access: yesAdvanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis   +3 more
wiley   +1 more source

Social choice and game theory: recent results with a topological approach [PDF]

open access: yes
This chapter presents a summary of recent results obtained in game and social choice theories, and highlights the application and the development of tools in algebraic topology.
Chichilnisky, Graciela
core   +1 more source

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

open access: yesFEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao   +4 more
wiley   +1 more source

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