Results 161 to 170 of about 10,954,273 (361)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

SocialPET: Socially Informed Pattern Exploiting Training for Few-Shot Stance Detection in Social Media [PDF]

arXiv
Stance detection, as the task of determining the viewpoint of a social media post towards a target as 'favor' or 'against', has been understudied in the challenging yet realistic scenario where there is limited labeled data for a certain target. Our work advances research in few-shot stance detection by introducing SocialPET, a socially informed ...
arxiv  

Second Birth Fertility in Germany: Social Class, Gender, and the Role of Economic Uncertainty. [PDF]

Eur J Popul, 2023
Kreyenfeld M, Konietzka D, Lambert P, Ramos VJ.   +3 more
europepmc   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Social Class, Gender and the Pace of Academic Life: What Kind of Solution is Slow?

Forum: Qualitative Social Research, 2014
My starting point for this article is the increasing pace of academic life. As the other articles in this special section evidence, the Slow movement, which seeks to challenge our contemporary obsession with speed, is being taken up by many in order to ...
Heather Mendick
doaj  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Problemas e limites da utilização do conceito de classe social em investigações epidemiológicas: uma revisão crítica da literatura

Cadernos de Saúde Pública
As limitações evidenciadas no emprego de variáveis empírico-indutivas nas alternativas hegemônicas da Epidemiologia para o tratamento das variações sócio-econômicas em coletivos humanos levaram à necessidade de novas propostas.
Jorge José Santos Pereira Solla
doaj  

the social organization of space: class, cognition, and residence in a Spanish town [PDF]

, 1977
David D. Gilmore
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

The relationship between social class, stress-anxiety responses, academic achievement, and internalization of professional attitudes of students in a medical school

, 1967
Marcel Fredericks, P Mundy
openalex   +1 more source