Results 161 to 170 of about 13,801,195 (403)

Social Relation Recognition in Egocentric Photostreams [PDF]

open access: yesarXiv, 2019
This paper proposes an approach to automatically categorize the social interactions of a user wearing a photo-camera 2fpm, by relying solely on what the camera is seeing. The problem is challenging due to the overwhelming complexity of social life and the extreme intra-class variability of social interactions captured under unconstrained conditions. We
arxiv  

Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells

open access: yesMolecular Oncology, EarlyView.
High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies   +9 more
wiley   +1 more source

Household wealth and adolescents' social-emotional functioning in schools. [PDF]

open access: yes, 2019
This study attempts a two-part shift in educational research narrowly fixated on the socioeconomic determinants of student test-score performance. First, we focus on variations in how to measure wealth. Second, we move beyond achievement and focus on the
Gottfried, Michael A, Ream, Robert K
core   +1 more source

On Social Class, Anno 2014

open access: yes, 2015
This article responds to the critical reception of the arguments made about social class in Savage et al. (2013). It emphasises the need to disentangle different strands of debate so as not to conflate four separate issues: (a) the value of the seven ...
Mike Savage   +7 more
semanticscholar   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

open access: yesMolecular Oncology, EarlyView.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Unraveling epigenetic heterogeneity across gastrointestinal adenocarcinomas through a standardized analytical framework

open access: yesMolecular Oncology, EarlyView.
This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto   +3 more
wiley   +1 more source

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

open access: yesMolecular Oncology, EarlyView.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores   +14 more
wiley   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

open access: yesMolecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park   +6 more
wiley   +1 more source

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