Results 181 to 190 of about 14,054,010 (381)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

The relationship between social class, average grade in college, medical college admission test scores, and academic achievement of students in a medical school

, 1967
Marcel Fredericks, P Mundy
openalex   +1 more source

Ethnicity and social class in the delivery of services: analysis of a child guidance clinic. [PDF]

, 1974
George H. Wolkon, Sharon Moriwaki, D M Mandel, J Archuleta, P Bunje, Sebastian Zimmermann   +5 more
openalex   +1 more source

"Stratification and Mortality - A Comparison of Education, Class, Status and Income" [PDF]

In many analyses of social inequality in health, different dimensions of social stratification have been used more or less interchangeably as measures of the individual’s general social standing.
Erikson, Robert, Torssander, Jenny
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Class and Politics in Wilhelmine Germany: The Center Party and the Social Democrats in Württemberg [PDF]

, 1976
David Blackbourn
openalex   +1 more source

Change and continuity in family formation among young adults in Britain

, 2003
Data from the 1958 and 1970 British birth cohorts permit comparison of family formation patterns among young adults. We present evidence of changes in the speed and extent to which young adults enter first partnership, marry and become parents, and the ...
Berrington, Ann
core  

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Sleep as a mediator of the relationship between social class and health in higher education students. [PDF]

Br J Psychol, 2023
McGuffog R, Rubin M, Boyes M, Caltabiano ML, Collison J, Lovell GP, Muldoon O, Paolini S.   +7 more
europepmc   +1 more source

Social class variables related to health instruction. [PDF]

, 1972
Darwin Dennison
openalex   +1 more source