Results 191 to 200 of about 3,908,561 (347)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Sleep as a mediator of the relationship between social class and health in higher education students. [PDF]

Br J Psychol, 2023
McGuffog R, Rubin M, Boyes M, Caltabiano ML, Collison J, Lovell GP, Muldoon O, Paolini S.   +7 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Blood lipid associations in 18 year-old men

Revista de Saúde Pública
The association of cigarette smoking, physical activity at work, and social class with total cholesterol and with high and low density lipoprotein cholesterol were examined in a random sample of 238 males, of 18 years of age, of Rosario, Argerntina.
Leonor Poletto, Stella Pezzotto, Julio Morini   +2 more
doaj  

Higher social class is associated with higher contextualized emotion recognition accuracy across cultures. [PDF]

PLoS One
Kafetsios K, Hess U, Alonso-Arbiol I, Schütz A, Gruda D, Campbell K, Chen BB, Dostal D, Held MJ, Hypsova P, Kamble S, Kimura T, Kirchner-Häusler A, Kyvelea M, Livi S, Mandal E, Ochnik D, Papageorgakopoulos N, Seitl M, Sakman E, Sumer N, Sulejmanov F, Theodorou A, Uskul AK.   +23 more
europepmc   +1 more source

Second Birth Fertility in Germany: Social Class, Gender, and the Role of Economic Uncertainty. [PDF]

Eur J Popul, 2023
Kreyenfeld M, Konietzka D, Lambert P, Ramos VJ.   +3 more
europepmc   +1 more source

Class Origin, Family Culture, and Intergenerational Correlation of Education in Rural China [PDF]

This paper examines the determinants of intergenerational correlation of education in rural China by using a data from a large survey of households. Three generations who completed education during the period from pre-1949 to the beginning of the 2000s ...
Li, Shi, Sato, Hiroshi
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

We need to talk about social class: Why theories of social class matter for understanding inequities in palliative and end-of-life care. [PDF]

Palliat Med
Bradshaw A, Richards N, Hussain JA, Davies JM.   +3 more
europepmc   +1 more source

The paradoxical effects of social class on career adaptability: The role of intolerance of uncertainty. [PDF]

Front Psychol, 2022
Wang R, Lin X, Wang L.
europepmc   +1 more source