Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu +6 more
wiley +1 more source
The impact of shared sense of agency and moral dispositions on intergroup dishonesty. [PDF]
Curr PsycholPiperno G +3 more
europepmc +1 more source
Multimorbidity and animal models
Animal Models and Experimental Medicine, EarlyView.Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang +7 more
wiley +1 more source
Media channels and the secondary transfer effect: influences on willingness to interact with Asian international students in Japan mediated by outgroup morality perception. [PDF]
BMC PsycholGao X, Takai J, Chen S.
europepmc +1 more source
Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention
Animal Models and Experimental Medicine, EarlyView.This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie +4 more
wiley +1 more source
Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study
Annals of Neurology, EarlyView.Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study assessed clinical, neuroimaging (3T‐magnetic resonance imaging [MRI], dopamine transporter single‐photon emission ...
Margherita Fabbri +26 more
wiley +1 more source
Naturalizing, Normativity, and Using What “We” Know in Ethics [PDF]
, 2000 Walker, Margaret Urban
core +1 more source
Turning Slowly Predicts Future Diagnosis of Parkinson's Disease: A Decade‐Long Longitudinal Analysis
Annals of Neurology, EarlyView.Objective Wearable technology allows accurate measurement of turning while walking, with cross‐sectional studies indicating that difficulty turning presents even in preclinical phases of Parkinson's disease. The aim of our study was to quantify rate of change of turning performance in a cohort of older adults, and test whether turning decline can ...
Morad Elshehabi +9 more
wiley +1 more source
Let Them Talk: Coping with PrEP-Related Stigma and Sustaining PrEP Persistence Among Men Who Have Sex with Men in Tanga, Tanzania. [PDF]
Healthcare (Basel)Kiondo F +5 more
europepmc +1 more source