Results 81 to 90 of about 167,984 (254)
, 2016 In this essay we provide (1) an argument for why ethics should be naturalized, (2) an analysis of why it is not yet naturalized, (3) a defense of ethical naturalism against two fallacies—Hume’s and Moore’s—that ethical naturalism allegedly commits, and ...
Flanagan, Owen +2 more
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What are ‘universalizable interests’? [PDF]
, 2000 Many of Habermas's critical commentators agree that Discourse Ethics fails as a theory of the validity of moral norms and only succeeds as a theory of the democratic legitimacy of socio‐political norms. The reason they give is that the moral principle (U)
Finlayson, James Gordon
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Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Advanced Science, EarlyView.Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu +14 more
wiley +1 more source
The Nature of Legal Dispute Bargaining [PDF]
, 2016 The longstanding debate over the relative merits of adversarial and communitarian theories of legal dispute bargaining has been in somewhat of a holding pattern for several years, but recent research in the field of cognitive neuroscience may break the ...
Condlin, Robert J
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Left threatened by Right: political intergroup bias in the contemporary Italian context. [PDF]
, 2019 Using different evaluation targets (i.e., politicians’ pictures, ideological words, items referring to features attributed to political ingroup/outgroup) we characterized the intergroup bias among political groups in the Italian context (Study 1-2-3) and
Giuseppina Porciello +4 more
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Advanced Science, EarlyView.This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang +9 more
wiley +1 more source
Ethics and the moral life [PDF]
, 1980 The article summarizes recent social scientific studies of the moral life, and pedogogies for moral education, in their relation to normative inquiry (ethics).
Hoehn, Richard A.
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Advanced Science, EarlyView.The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang +7 more
wiley +1 more source
The Limits of Emotion in Moral Judgment [PDF]
, 2018 I argue that our best science supports the rationalist idea that, independent of reasoning, emotions aren’t integral to moral judgment. There’s ample evidence that ordinary moral cognition often involves conscious and unconscious reasoning about an ...
May, Joshua
core
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source