Results 91 to 100 of about 3,275,107 (307)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Social engagement revealed by gaze following in third-party observers of simulated social conflict. [PDF]

open access: yesFront Psychol, 2022
Champ TM   +5 more
europepmc   +1 more source

ORGANIC FARMING AND SOCIAL CAPITAL APPROACH IN THE RESTORATION OF SUSTAINABLE AGRICULTURAL LIVELIHOODS IN A POST-CONFLICT SETTING: A CASE OF NORTHERN UGANDA [PDF]

open access: yes, 2012
This report presents a discussion of how organic farming and social capital development can contribute towards the restoration of sustainable agricultural livelihoods in a post-conflict setting; with a case study of Northern Uganda.
Odokonyero, Kennedy
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Indigenous Theologies in Indonesia: Syncretism, State Recognition, and the Resilience of Aliran Kepercayaan [PDF]

open access: yesPharos Journal of Theology
This article provides a thorough examination of indigenous theology in Indonesia by focusing on the following six belief systems: Kejawen, Sunda Wiwitan, Kaharingan, Marapu, Ada’ Mappurondo, and Parmalim.
Cindy Vebyola Batubara   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Exploring motivated reasoning in polarization over the unfolding 2023 judicial reform in Israel

open access: yesCommunications Psychology
This work explored polarization over Israel’s Judicial Reform, introduced in January 2023. We find that the reform divided people into pro- and anti-reform camps, which differed in characteristics such as institutional trust, patriotism, and national ...
Dora Simunovic   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy