Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Mice in social conflict show rule-observance behavior enhancing long-term benefit. [PDF]
Nat Commun, 2017 Choe IH +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Weak dorsolateral prefrontal response to social criticism predicts worsened mood and symptoms following social conflict in people at familial risk for schizophrenia. [PDF]
Neuroimage Clin, 2018 Nook EC +5 more
europepmc +1 more source
Social Agency and Psychosocial Recovery: A Resilient Perspective on the Social Determinants of Mental Health in a Community Affected by the Colombian Armed Conflict [PDF]
Diana Marcela Bedoya-Gallego +2 more
openalex +1 more source
SOCIAL CONFLICT MANAGEMENT TRAINING FOR RESIDENTS OF PAROPO-RAMA SETTLEMENT, MAKASSAR CITY
, 2023 Ichlas Afandi +5 more
openalex +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Individual clown anemonefish shrink to survive heat stress and social conflict. [PDF]
Sci AdvVersteeg MA +4 more
europepmc +1 more source
Building the microbiome in health and disease: niche construction and social conflict in bacteria. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2015 McNally L, Brown SP.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source