Results 151 to 160 of about 3,275,107 (307)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Transcriptomic Analysis Reveals Sex-Dependent Expression Patterns in the Basolateral Amygdala of Dominant and Subordinate Animals After Acute Social Conflict. [PDF]

Mol Neurobiol, 2019
McCann KE, Sinkiewicz DM, Rosenhauer AM, Beach LQ, Huhman KL.   +4 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Editorial: Pro-democracy movements in a comparative perspective

Frontiers in Political Science, 2023
Sonja Grimm, Sebastian Hellmeier, Jan Matti Dollbaum, Véronique Dudouet   +3 more
doaj   +1 more source

Mice in social conflict show rule-observance behavior enhancing long-term benefit. [PDF]

Nat Commun, 2017
Choe IH, Byun J, Kim KK, Park S, Kim I, Jeong J, Shin HS.   +6 more
europepmc   +1 more source

Robert Aumann and Thomas Schelling: Conflict and cooperation through the lens of game theory [PDF]

The Prize in Economic Sciences 2005: supplementary information to press release. Robert Aumann and Thomas Schelling have contributed to enhancing our understanding of conflict and cooperation. They have achieved this by extending and applying game theory
Committee, Nobel Prize
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Individual clown anemonefish shrink to survive heat stress and social conflict. [PDF]

Sci Adv
Versteeg MA, MacDonald C, Bennett-Smith MF, Buston PM, Rueger T.   +4 more
europepmc   +1 more source

Weak dorsolateral prefrontal response to social criticism predicts worsened mood and symptoms following social conflict in people at familial risk for schizophrenia. [PDF]

Neuroimage Clin, 2018
Nook EC, Dodell-Feder D, Germine LT, Hooley JM, DeLisi LE, Hooker CI.   +5 more
europepmc   +1 more source

On the Theory of Ethnic Conflict [PDF]

We present a theory of ethnic conflict in which coalitions formed along ethnic lines compete for the economy%u2019s resources. The role of ethnicity is to enforce coalition membership: in ethnically homogeneous societies members of the losing coalition ...
Francesco Caselli, Wilbur John Coleman II   +1 more
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