Results 81 to 90 of about 518,499 (284)

Does Size Matter? School Consolidation Policy Issues in Arkansas [PDF]

, 2004
Providing a reasonable education for all students in Arkansas is a legal responsibility explicitly mandated by the state’s constitution. Consistent with the long-standing American tradition of “grassroots” control of education, public schools in all ...
Barnett, Joshua H., Lucas, Christopher J., Ritter, Gary W.   +2 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Theoretical Logic and Implementation Path of Comprehensive Land Consolidation for Promoting Common Prosperity: A Case Study of Ningbo City

Land
Eliminating poverty and achieving social justice are global concerns. China has focused on common prosperity. Comprehensive land consolidation is a potential policy tool that can contribute to common prosperity, but its effectiveness and implementation ...
Xiaoping Zhou, Yu Lv, Jieyu Zou, Xiaokun Gu   +3 more
doaj   +1 more source

Assessing fiscal episodes [PDF]

In an OCDE panel, for the period 1970-2010, we assess the effects of fiscal consolidation episodes, with four different definitions. Our results reveal that lower final government consumption would increase private consumption in three out of the four ...
António Afonso, João Tovar Jalles
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Optimal experience and personal growth. Flow and the consolidation of place identity [PDF]

, 2016
This study examined the relationship between flow experience and place identity, based on eudaimonistic identity theory (EIT) which prioritizes self-defining activities as important for an individual's identification of his/her goals, values, beliefs ...
Aristotle, Barber, Bonaiuto, Bonaiuto, Bonaiuto, Bonaiuto, Bonnes, Bonnes, Brislin, Coatsworth, Coatsworth, Cooper, Craig, Csikszentmihalyi, Csikszentmihalyi, Csikszentmihalyi, Csikszentmihalyi, Csikszentmihalyi, Csikszentmihalyi, Csikszentmihalyi, Csikszentmihalyi, Csikszentmihalyi, Csikszentmihalyi, Davidson, Deci, Deci, Deci, Deci, Delle Fave, Delle Fave, Demerouti, Diener, Dimitrakopoulou, Dixon, Eccles, Erikson, Erikson, Fornara, Fraser, Fredricks, Giuliani, Giuliani, Hamari, Hansen, Harari, Harmison, Hernández, Huta, Irwin, Jackson, Jorgensen, Kowal, Kyle, Kyle, Kyle, Kyle, Lee, Mao, Mao, Martin, Maslow, Massimini, Nakamura, Nakamura, Nielsen, Norton, OECD, Prezza, Prezza, Proshansky, Proshansky, Proshansky, Ross, Russell, Ryff, Ryff, Schwartz, Schwartz, Seligman, Sharp, Skadberg, Stedman, Tietze, Twigger-Ross, Waterman, Waterman, Waterman, Waterman, Waterman, Waterman, Waterman, Waterman, Waterman, Waterman, Waterman, Williams, Wöran   +96 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Identification of stagnation reasons in the field of land consolidation in Slovakia compared with the Czech Republic

Journal of Water and Land Development, 2017
Causes of different evolution of land consolidation in the Czech Republic (CR) and Slovakia (SR) are documented and analyzed. Land fragmentation, methodical guidelines, legislative measures, financing and implementation of land consolidation projects are
Muchová Zlatica, Leitmanová Mária, Jusková Kateřina, Konc Ľubomír, Vašek Andrej   +4 more
doaj   +1 more source